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1. (WO2007093630) DESTRUCTION OF TUMOR CELLS EXPRESSING LOW TO MEDIUM LEVELS OF TUMOR ASSOCIATED TARGET ANTIGENS BY TRIFUNCTIONAL BISPECIFIC ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/093630    International Application No.:    PCT/EP2007/051483
Publication Date: 23.08.2007 International Filing Date: 15.02.2007
IPC:
A61K 39/395 (2006.01), A61P 35/00 (2006.01), C07K 16/30 (2006.01), C07K 16/32 (2006.01), C07K 16/28 (2006.01), C07K 16/46 (2006.01)
Applicants: TRION PHARMA GMBH [DE/DE]; Frankfurter Ring 193a, 80807 Muenchen (DE) (For All Designated States Except US).
LINDHOFER, Horst [DE/DE]; (DE) (For US Only)
Inventors: LINDHOFER, Horst; (DE)
Agent: BEHNISCH, Werner; Reinhard, Skuhra, Weise & Partner GbR, Friedrichstrasse 31, 80801 München (DE)
Priority Data:
06003057.4 15.02.2006 EP
Title (EN) DESTRUCTION OF TUMOR CELLS EXPRESSING LOW TO MEDIUM LEVELS OF TUMOR ASSOCIATED TARGET ANTIGENS BY TRIFUNCTIONAL BISPECIFIC ANTIBODIES
(FR) DESTRUCTION DE CELLULES TUMORALES EXPRIMANT DES NIVEAUX FAIBLES À MOYENS D'ANTIGÈNES CIBLES ASSOCIÉS À DES TUMEURS, PAR DES ANTICORPS TRIFONCTIONNELS BISPÉCIFIQUES
Abstract: front page image
(EN)The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases. It has been found that said trifunctional bispecific antibodies are binding to tumor-associated antigens selected from Her2/neu, CD20, EpCAM, G250, proteoglycans, GD3, GD2, MHC II, EGF-R and CEA, wherein said tumor-associated antigens are expressed on said tumor cell with a low to medium expression level only.
(FR)La présente invention concerne l'utilisation d'anticorps bispécifiques trifonctionnels pour préparer une composition pharmaceutique pour la prophylaxie et le traitement de maladies tumorales. On a déterminé que lesdits anticorps bispécifiques trifonctionnels se lient à des antigènes associés à des tumeurs, sélectionnés parmi Her2/neu, CD20, EpCAM, G250, protéoglycans, GD3, GD2, MHC II, EGF-R et CEA, lesdits antigènes associés à des tumeurs étant exprimés sur lesdites cellules tumorales à un niveau faible ou moyen d'expression uniquement.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)