WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007093452) IMPROVED PROCESS FOR THE PREPARATION OF STABLE NITROXYL RADICALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/093452    International Application No.:    PCT/EP2007/001879
Publication Date: 23.08.2007 International Filing Date: 09.02.2007
IPC:
C07D 209/44 (2006.01)
Applicants: POLIMERI EUROPA S.P.A. [IT/IT]; Piazza Boldrini 1, I-20097 San Donato Milanese-Milano (IT) (For All Designated States Except US).
CALDARARO, Maria [IT/IT]; (IT) (For US Only).
PO', Riccardo [IT/IT]; (IT) (For US Only).
RICCI, Marco [IT/IT]; (IT) (For US Only)
Inventors: CALDARARO, Maria; (IT).
PO', Riccardo; (IT).
RICCI, Marco; (IT)
Agent: DE GREGORI, Antonella; Barzano'& Zanardo Milano S.P.A., Via Borgonuovo 10, I-20121 Milano (IT)
Priority Data:
MI2006A000285 16.02.2006 IT
Title (EN) IMPROVED PROCESS FOR THE PREPARATION OF STABLE NITROXYL RADICALS
(FR) PROCEDE AMELIORE DE PREPARATION DE RADICAUX NITROXYLE STABLES
Abstract: front page image
(EN)Process for the preparation of stable nitroxyl radicals (I) starting from N-benzylphthalimide in two steps. In the first step, the intermediate N-benzyl-1, 1, 3, 3-tetra- alkylisoindoline is prepared by treatment with a Grignard reagent, prepared in methyl-tert-butyl ether, of N- benzylphthalimide, obtained in the same reaction environ - ment starting from phthalic anhydride and benzylamine. In the second step, the N-benzyl-1, 1, 3 , 3-tetra- alkylisoindoline is transformed into the nitroxyl radical by hydrogenolysis and subsequent oxidation with hydrogen peroxide in the presence of a catalyst selected from acids and salts of polymolybdic or polytungstic acids.
(FR)L'invention concerne un procédé de préparation de radicaux nitroxyle stables (I), à partir de N-benzylphtalimide et en deux étapes. La première étape consiste à préparer un intermédiaire, la N-benzyl-1,1,3,3-tétra-alkylisoindoline par traitement, avec un réactif de Grignard préparé dans l'oxyde de méthyle et de tert-butyle, du N- benzylphtalimide, lui-même obtenu dans le même environnement réactionnel à partir d'anhydride phtalique et de benzylamine. La seconde étape consiste à transformer la N-benzyl-1,1,3,3-tétraalkylisoindoline en radical nitroxyle par hydrogénolyse, puis oxydation par le peroxyde d'hydrogène en présence d'un catalyseur choisi parmi les formes acides ou sels d'acides polymolybdiques et polytungsténiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)