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1. (WO2007092939) ANTIGENIC GM-CSF PEPTIDES AND ANTIBODIES TO GM-CSF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/092939    International Application No.:    PCT/US2007/061874
Publication Date: 16.08.2007 International Filing Date: 08.02.2007
Chapter 2 Demand Filed:    12.06.2007    
IPC:
C07K 16/00 (2006.01), C07K 16/24 (2006.01), A61K 39/395 (2006.01), A61P 35/02 (2006.01), A61P 29/00 (2006.01), A61P 11/06 (2006.01), A61P 37/02 (2006.01)
Applicants: MORPHOTEK, INC. [US/US]; 210 Welsh Pool Road, Exton, PA 19341 (US) (For All Designated States Except US).
SASS, Philip, M. [US/US]; (US) (For US Only).
NICOLAIDES, Nicholas, E. [US/US]; (US) (For US Only).
GRASSO, Luigi [IT/US]; (US) (For US Only).
LI, Jian [US/US]; (US) (For US Only).
CHAO, Qimin [US/US]; (US) (For US Only).
ROUTHIER, Eric [US/US]; (US) (For US Only).
EBEL, Wolfgang [DE/US]; (US) (For US Only)
Inventors: SASS, Philip, M.; (US).
NICOLAIDES, Nicholas, E.; (US).
GRASSO, Luigi; (US).
LI, Jian; (US).
CHAO, Qimin; (US).
ROUTHIER, Eric; (US).
EBEL, Wolfgang; (US)
Agent: CALDWELL, John, W.; Woodcock Washburn LLP, 12th Floor, Cira Centre, 2929 Arch Street, Philadelphia, PA 19104 (US)
Priority Data:
60/771,251 08.02.2006 US
60/774,500 17.02.2006 US
Title (EN) ANTIGENIC GM-CSF PEPTIDES AND ANTIBODIES TO GM-CSF
(FR) PEPTIDES ANTIGÉNIQUES DU FACTEUR DE STIMULATION DE COLONIE DE GRANULOCYTES (GM-CSF) ET ANTICORPS AU GM-CSF
Abstract: front page image
(EN)Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.
(FR)La présente invention concernes des lignées d'hybridomes sécrétant des anticorps monoclonaux humains avec une haute spécificité de liaison et d'activité biologique, notamment une activité neutralisante contre le facteur de stimulation de colonies de granulocytes, et des procédé de génération des lignées d'hybridomes. L'invention concerne également des antigènes et des épitopes cibles. Les anticorps peuvent être utilisés dans des procédés thérapeutiques, par exemple, dans le traitement du cancer, de maladie infectieuse, et de maladie autoimmunitaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)