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1. (WO2007092932) BIVALENT ERBB LIGAND BINDING MOLECULES AND METHODS FOR THEIR PREPARATION AND USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/092932    International Application No.:    PCT/US2007/061863
Publication Date: 16.08.2007 International Filing Date: 08.02.2007
Chapter 2 Demand Filed:    08.02.2007    
IPC:
C12P 21/06 (2006.01), C07K 1/00 (2006.01)
Applicants: TARGETED MOLECULAR DIAGNOSTICS, LLC [US/US]; 610 Oakmont Lane, Westmont, Illinois 60559 (US) (For All Designated States Except US).
YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; Weizmann Institute Of Science, P.O. Box 95, 76100 Rehovot (IL) (For All Designated States Except US).
BACUS, Sarah S. [US/US]; (US) (For US Only).
HILL, Jason, E. [US/US]; (US) (For US Only).
YARDEN, Yosef [IL/IL]; (IL) (For US Only).
KOCHUPURAKKAL, Bose, S. [IN/IN]; (IN) (For US Only)
Inventors: BACUS, Sarah S.; (US).
HILL, Jason, E.; (US).
YARDEN, Yosef; (IL).
KOCHUPURAKKAL, Bose, S.; (IN)
Agent: GOULD, Robert, M.; Bell, Boyd & Lloyd LLC, P.O. Box 1135, Chicago, Illinois 60690-1135 (US)
Priority Data:
60/771,237 08.02.2006 US
60/828,343 05.10.2006 US
Title (EN) BIVALENT ERBB LIGAND BINDING MOLECULES AND METHODS FOR THEIR PREPARATION AND USE
(FR) MOLECULES DE LIAISON DE LIGAND ERBB BIVALENTES ET PROCEDES DESTINES A LEUR PREPARATION ET LEUR UTILISATION
Abstract: front page image
(EN)A new bivalent ErbB-based ligand binding molecule is disclosed along with its method of preparation and use. The binding molecule can be a protein expressed from a recombinant DNA molecule. The protein can contain two extracellular domains of an ErbB receptor that both bind to ErbB receptor ligands. These binding molecules act as traps to bind and sequester ligands, thus making them unavailable for binding to cellular ErbB receptors.
(FR)La présente invention concerne une molécule de liaison de ligand ErbB bivalente ainsi que son procédé de préparation et son utilisation. La molécule de liaison peut être une protéine exprimée à partir d'une molécule d'ADN recombiné. La protéine peut contenir deux domaines extracellulaires d'un récepteur ErbB qui se lient tous deux aux ligands du récepteur ErbB. Ces molécules de liaison agissent telles des pièges qui lient et emprisonnent les ligands, les rendant ainsi indisponibles pour toute liaison avec les récepteurs cellulaires ErbB.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)