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1. (WO2007092846) 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/092846    International Application No.:    PCT/US2007/061691
Publication Date: 16.08.2007 International Filing Date: 06.02.2007
IPC:
C07D 215/38 (2006.01), C07D 401/12 (2006.01), C07D 405/06 (2006.01), C07D 405/14 (2006.01), A61K 31/47 (2006.01), A61K 31/4709 (2006.01), A61P 25/28 (2006.01)
Applicants: JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30, B-B2340 Beerse (BE) (For All Designated States Except US).
BAXTER, Ellen [US/US]; (US) (For US Only).
REITZ, Allen, B. [US/US]; (US) (For US Only).
CREIGHTON, Christopher, John [US/US]; (US) (For US Only)
Inventors: BAXTER, Ellen; (US).
REITZ, Allen, B.; (US).
CREIGHTON, Christopher, John; (US)
Agent: JOHNSON, Philip, S.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, New Jersey 08933 (US)
Priority Data:
60/765,650 06.02.2006 US
Title (EN) 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
(FR) DÉRIVÉS DE 2-AMINO-3,4-DIHYDRO-QUINOLÉINE UTILES COMME INHIBITEURS DE LA β-SÉCRÉTASE (BACE)
Abstract: front page image
(EN)The present invention is directed to 2-amino-3,4-dihydro-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as b-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
(FR)La présente invention concerne des dérivés de 2-amino-3,4-dihydro-quinoléine, des compositions pharmaceutiques contenant ces dérivés et leur utilisation dans le traitement de la maladie d'Alzheimer et de troubles associés. Les composés de la présente invention sont des inhibiteurs de la β-sécrétase, aussi connue sous les noms d'enzyme de clivage du site β, BACE, BACE 1, Asp 2 et mémapsine 2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)