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1. WO2007091697 - METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE

Publication Number WO/2007/091697
Publication Date 16.08.2007
International Application No. PCT/JP2007/052432
International Filing Date 06.02.2007
IPC
C07D 307/93 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
93condensed with a ring other than six-membered
C07D 311/94 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
94condensed with rings other than six-membered or with ring systems containing such rings
C07C 405/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
405Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
CPC
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07C 405/0025
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
405Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
0025containing keto groups
C07D 307/93
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
93condensed with a ring other than six-membered
C07D 307/935
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
93condensed with a ring other than six-membered
935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
C07D 309/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
309Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02having no double bonds between ring members or between ring members and non-ring members
08with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
10Oxygen atoms
12only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
C07D 311/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
94condensed with rings other than six-membered
Applicants
  • R-TECH UENO, LTD. [JP]/[JP] (AllExceptUS)
  • HIRATA, Ryu [JP]/[JP] (UsOnly)
  • MATSUKAWA, Tatsuya [JP]/[JP] (UsOnly)
  • MASUZAKI, Kazuhiro [JP]/[JP] (UsOnly)
  • UENO, Ryuji [JP]/[US] (UsOnly)
Inventors
  • HIRATA, Ryu
  • MATSUKAWA, Tatsuya
  • MASUZAKI, Kazuhiro
  • UENO, Ryuji
Agents
  • TANAKA, Mitsuo
Priority Data
60/765,72807.02.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE
(FR) MÉTHODE DE PRÉPARATION DE DÉRIVÉS DE PROSTAGLANDINE
Abstract
(EN)
Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
(FR)
L'invention porte sur une méthode de préparation d'un dérivé de prostaglandine de formule (A) consistant à faire réagir un aldéhyde de formule (I) avec un 2-oxoalkyl phosphonate dans un solvant de réaction, en présence d'un hydroxyde alcalin formant la seule base. L'utilisation de l'hydroxyde alcalin comme seule base dans le système réactif permet d'obtenir ledit dérivé par des procédures simples et avec un fort rendement.
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