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1. WO2007091661 - SUGAR CHAIN-MODIFIED LIPOSOME SUITABLE FOR MOLECULAR IMAGING AND UTILIZATION AND PRODUCTION OF THE SAME

Publication Number WO/2007/091661
Publication Date 16.08.2007
International Application No. PCT/JP2007/052289
International Filing Date 08.02.2007
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 47/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42107; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 47/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
549Sugars, nucleosides, nucleotides or nucleic acids
A61K 47/6911
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
A61K 49/0084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0063characterised by a special physical or galenical form, e.g. emulsions, microspheres
0069the agent being in a particular physical galenical form
0076dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
0084liposome, i.e. bilayered vesicular structure
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/1277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1277Processes for preparing; Proliposomes
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • 独立行政法人産業技術総合研究所 NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY [JP]/[JP] (AllExceptUS)
  • 片山化学工業株式会社 KATAYAMA CHEMICAL INDUSTRIES CO., LTD. [JP]/[JP] (AllExceptUS)
  • 山嵜 登 YAMAZAKI, Noboru [JP]/[JP] (UsOnly)
  • 大家 一典 OIE, Kazunori [JP]/[JP] (UsOnly)
Inventors
  • 山嵜 登 YAMAZAKI, Noboru
  • 大家 一典 OIE, Kazunori
Agents
  • 山本 秀策 YAMAMOTO, Shusaku
Priority Data
2006-03176508.02.2006JP
2006-22631923.08.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SUGAR CHAIN-MODIFIED LIPOSOME SUITABLE FOR MOLECULAR IMAGING AND UTILIZATION AND PRODUCTION OF THE SAME
(FR) LIPOSOME MODIFIÉ PAR UNE CHAÎNE DE SUCRE CONVENANT POUR L'IMAGERIE MOLÉCULAIRE ET UTILISATION ET PRODUCTION DE CELUI-CI
(JA) 分子イメージングに適した糖鎖修飾リポソームならびにその利用および製造
Abstract
(EN)
It is intended to provide a molecular imaging agent. Namely, there is provided a sugar chain-modified liposome comprising a liposome, a sugar chain group, a linker protein group and a hydrophilic compound group, wherein the linker protein group attaches to the outer face of the liposome, the sugar chain group attaches to at least a part of the linker protein group, and the hydrophilic compound group attaches to the outer face of the liposome or a part of the linker protein group. In another aspect, a medicinal composition which comprises the sugar chain-modified liposome together with a pharmaceutically active ingredient is provided. In a still another aspect, a sugar chain-modified liposome to be used as a molecular imaging agent is provided. In a still another aspect, a method of producing a liposome containing a labeled sugar chain is provided.
(FR)
L'invention concerne un produit pour l'imagerie moléculaire. Plus précisément, l'invention concerne un liposome modifié par une chaîne de sucre comprenant un liposome, un groupe chaîne de sucre, un groupe protéine de liaison et un groupe composé hydrophile, le groupe protéine de liaison se fixant à la face externe du liposome, le groupe chaîne de sucre se fixant à au moins une partie du groupe protéine de liaison et le groupe composé hydrophile se fixant à la face externe du liposome ou à une partie du groupe protéine de liaison. Dans un autre aspect, l'invention concerne une composition médicinale qui comprend le liposome modifié par une chaîne de sucre ainsi qu'un ingrédient actif du point de vue pharmaceutique. Dans encore un autre aspect, l'invention concerne un liposome modifié par une chaîne de sucre à utiliser en tant que produit pour l'imagerie moléculaire. Dans encore un autre aspect, l'invention concerne un procédé de production d'un liposome contenant une chaîne de sucre marquée.
(JA)
本発明は、分子イメージ剤を提供することを課題とする。本発明により、リポソームと、糖鎖基と、リンカータンパク質基と、親水性化合物基とを含み、該リンカータンパク質基は該リポソームの外表面に結合し、該リンカータンパク質基の少なくとも一部に該糖鎖基が結合し、該リポソームの外表面または該リンカータンパク質基の一部に該親水性化合物基が結合している、糖鎖修飾リポソームが提供される。本発明の1つの局面により、糖鎖修飾リポソームと医薬活性成分をさらに含む薬学的組成物が提供される。本発明の1つの局面により、分子イメージング剤として使用される糖鎖修飾リポソームが提供される。本発明の1つの局面により、標識された糖鎖を含むリポソームを生産する方法が提供される。
Also published as
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