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1. WO2007091313 - CYTOKINE PRODUCTION INHIBITOR AND HETEROCYCLIC PHENOXY DERIVATIVE

Publication Number WO/2007/091313
Publication Date 16.08.2007
International Application No. PCT/JP2006/302156
International Filing Date 08.02.2006
IPC
A61K 31/423 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61K 31/428 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07D 263/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • 株式会社 静岡カフェイン工業所 SHIZUOKA COFFEIN CO., LTD [JP]/[JP] (AllExceptUS)
  • 中戸川 清 NAKATOGAWA, Kiyoshi [JP]/[JP] (UsOnly)
  • 高木 正道 TAKAGI, Masamichi [JP]/[JP] (UsOnly)
  • 赤嶋 真 AKASHIMA, Makoto [JP]/[JP] (UsOnly)
Inventors
  • 中戸川 清 NAKATOGAWA, Kiyoshi
  • 高木 正道 TAKAGI, Masamichi
  • 赤嶋 真 AKASHIMA, Makoto
Agents
  • 浅村 皓 ASAMURA, Kiyoshi
Priority Data
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) CYTOKINE PRODUCTION INHIBITOR AND HETEROCYCLIC PHENOXY DERIVATIVE
(FR) INHIBITEUR DE LA PRODUCTION DE CYTOKINES ET DÉRIVÉ PHÉNOXY HÉTÉROCYCLIQUE
(JA) サイトカイン産生阻害剤及びヘテロ環式フェノキシ誘導体
Abstract
(EN)
A heterocyclic phenoxy derivative represented by the formula (1a): (1a) wherein Y represents an oxygen or sulfur atom; (R1)m represents a hydrogen or halogen atom, an alkyl group or the like; (R2)n represents a hydrogen or halogen atom, an alkyl group or the like; and Z represents an alkylene group or the like. The derivative has an excellent inhibitory effect on the inflammatory cytokine production, and therefore can be used as a therapeutic agent for any of various inflammatory diseases, autoimmune disease, diabetes, cancer and others.
(FR)
Dérivé phénoxy hétérocyclique représenté par la formule (1a) : (1a) dans laquelle Y représente un atome d'oxygène ou de soufre ; (R1)m représente un atome d'hydrogène ou d'halogène, un groupe alkyle ou similaire ; (R2)n représente un atome d'hydrogène ou d'halogène, un groupe alkyle ou similaire ; et Z représente un groupe alkylène ou similaire. Le dérivé a un excellent effet d'inhibition sur la production de cytokines inflammatoires et peut par conséquent être utilisé comme agent thérapeutique pour diverses maladies inflammatoires, une maladie auto-immune, le diabète, un cancer, entre autres.
(JA)
not available
Also published as
Latest bibliographic data on file with the International Bureau