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1. (WO2007091269) NOVEL TANDEM siRNAS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/091269 International Application No.: PCT/IL2007/000184
Publication Date: 16.08.2007 International Filing Date: 08.02.2007
IPC:
C07H 21/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants:
AYGUN, HUSEYIN [TR/DE]; DE (UsOnly)
FEINSTEIN, Elena [IL/IL]; IL (UsOnly)
QUARK PHARMACEUTICALS, INC. [US/US]; 6501 Dumbarton Circle Fremont, CA 94555, US (AllExceptUS)
Inventors:
AYGUN, HUSEYIN; DE
FEINSTEIN, Elena; IL
Common
Representative:
QUARK BIOTECH, INC.; Dr. Judith Abrahams (QBI Enterprises Ltd.) Weizmann Science Park P.o.box 4071 70400-Nes Ziona, IL
Priority Data:
60/771,23808.02.2006US
Title (EN) NOVEL TANDEM siRNAS
(FR) NOVEAU TANDEM d'ARNsi
Abstract:
(EN) The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of two or more target genes. In particular, the present invention discloses tandem oligoribonucleotides which encode two or more inhibitory RNA molecules such as siRNAs, wherein each siRNA may be specific for a different gene. The sense and antisense segments in the siRNAs are connected via either a nucleotide or non-nucleotide linker.
(FR) La présente invention concerne de nouvelles molécules, compositions, procédés et applications destinés à traiter des troubles microvasculaires, des maladies oculaires et des affections des voies respiratoires utilisant l'inhibition d'au moins deux gènes cibles.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)