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1. (WO2007091269) NOVEL TANDEM siRNAS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/091269    International Application No.:    PCT/IL2007/000184
Publication Date: 16.08.2007 International Filing Date: 08.02.2007
IPC:
C07H 21/04 (2006.01)
Applicants: QUARK PHARMACEUTICALS, INC. [US/US]; 6501 Dumbarton Circle, Fremont, CA 94555 (US) (For All Designated States Except US).
AYGUN, HUSEYIN [TR/DE]; (DE) (For US Only).
FEINSTEIN, Elena [IL/IL]; (IL) (For US Only)
Inventors: AYGUN, HUSEYIN; (DE).
FEINSTEIN, Elena; (IL)
Common
Representative:
QUARK BIOTECH, INC.; Dr. Judith Abrahams, (QBI Enterprises Ltd.), Weizmann Science Park, P.o.box 4071, 70400-Nes Ziona (IL)
Priority Data:
60/771,238 08.02.2006 US
Title (EN) NOVEL TANDEM siRNAS
(FR) NOVEAU TANDEM d'ARNsi
Abstract: front page image
(EN)The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of two or more target genes. In particular, the present invention discloses tandem oligoribonucleotides which encode two or more inhibitory RNA molecules such as siRNAs, wherein each siRNA may be specific for a different gene. The sense and antisense segments in the siRNAs are connected via either a nucleotide or non-nucleotide linker.
(FR)La présente invention concerne de nouvelles molécules, compositions, procédés et applications destinés à traiter des troubles microvasculaires, des maladies oculaires et des affections des voies respiratoires utilisant l'inhibition d'au moins deux gènes cibles.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)