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Machine translation
1. (WO2007090872) ANTIBODIES AGAINST SECRETED FRI ZZLED RELATED PROTEIN-4 (SFRP-4 )
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/090872    International Application No.:    PCT/EP2007/051229
Publication Date: 16.08.2007 International Filing Date: 08.02.2007
IPC:
C07K 16/18 (2006.01), A61K 39/395 (2006.01), G01N 33/53 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (For All Designated States Except US).
ZAAR, Annette [DE/DE]; (DE) (For US Only).
HILLENBRAND, Rainer [DE/CH]; (CH) (For US Only).
VITALITI, Alessandra [CH/CH]; (CH) (For US Only)
Inventors: ZAAR, Annette; (DE).
HILLENBRAND, Rainer; (CH).
VITALITI, Alessandra; (CH)
Agent: BOURGAREL, Denis; NOVARTIS AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
60/771,651 09.02.2006 US
Title (EN) ANTIBODIES AGAINST SECRETED FRI ZZLED RELATED PROTEIN-4 (SFRP-4 )
(FR) AGENTS DE LIAISON DE LA PROTEINE-4 APPARENTEE A FRIZZLED (SFRP-4)
Abstract: front page image
(EN)This invention relates generally to the preparation of SFRP-4-binding agents and uses of the same. In particular the present invention relates to the preparation of anti-SFRP-4 antibodies and their use for SFRP-4 detection and modulation of SFRP-4-mediated function. The compositions and methods of the invention can be employed in diverse tissues to detect disorders manifested by altered SFRP-4 polypeptide expression as well as to affect therapeutic and prophylactic relief for such SFRP-4 polypeptide-associated disorders in a subject in need thereof.
(FR)La présente invention concerne de manière générale la préparation d'agents de liaison du SFRP-4 et leur utilisation. L'invention porte en particulier sur la préparation d'anticorps anti-SFRP-4 et de leur utilisation pour détecter le SFRP-4 et moduler les fonctions induites par le SFRP-4. Les compositions et les procédés de l'invention peuvent être utilisés dans divers tissus en vue de détecter des troubles manifestés par une modification de l'expression du polypeptide SFRP-4 et également de traiter et prévenir de tels troubles associés au polypeptide SFRP-4 chez un sujet nécessitant un tel traitement.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)