WO2007090854 AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

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Publication Number WO/2007/090854

Publication Date 16.08.2007

International Application No. PCT/EP2007/051184

International Filing Date 07.02.2007

IPC

CPC

Applicants

Cellzome (Uk) Ltd. (AllExceptUS)
REID, Alison [GB]/[GB] (UsOnly)
WILSON, Francis [GB]/[GB] (UsOnly)
DYKE, Hazel [GB]/[GB] (UsOnly)
PRICE, Steve [GB]/[GB] (UsOnly)
CRAMP, Sue [GB]/[GB] (UsOnly)

Inventors

REID, Alison
WILSON, Francis
DYKE, Hazel
PRICE, Steve
CRAMP, Sue

Agents

HUHN, Michael

Priority Data

06101510.3		10.02.2006		EP
06114491.1		24.05.2006		EP

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

(FR) COMPOSÉS D'AMINO PYRIMIDINE D'AZÉTIDINE DESTINÉS À TRAITER DES TROUBLES INFLAMMATOIRES

Abstract

(EN) The present invention relates to novel azetidine amino pyrimidine compounds of formula (I) for the modulation of the histamine H4 receptor and the treatment or prevention of conditions mediated by the histamine H4 receptor. The invention also relates to the preparation of such compounds.

(FR) L'invention concerne de nouveaux composés d'amino pyrimidine d'azétidine de formule (I) destinés à moduler le récepteur H4 de l'histamine. Ces composés sont destinés à traiter ou à prévenir des troubles médiés par le récepteur H4 de l'histamine. L'invention concerne également la préparation de tels composés.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
491	Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29	Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
491	Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

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1. WO2007090854 - AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS