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1. WO2007090854 - AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

Publication Number WO/2007/090854
Publication Date 16.08.2007
International Application No. PCT/EP2007/051184
International Filing Date 07.02.2007
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 491/04 (2006.01)
A61K 31/519 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 491/04
Applicants
  • Cellzome (Uk) Ltd.; Chesterford Research Park Little Chesterford Cambridgeshire CB10 1XL, GB (AllExceptUS)
  • REID, Alison [GB/GB]; GB (UsOnly)
  • WILSON, Francis [GB/GB]; GB (UsOnly)
  • DYKE, Hazel [GB/GB]; GB (UsOnly)
  • PRICE, Steve [GB/GB]; GB (UsOnly)
  • CRAMP, Sue [GB/GB]; GB (UsOnly)
Inventors
  • REID, Alison; GB
  • WILSON, Francis; GB
  • DYKE, Hazel; GB
  • PRICE, Steve; GB
  • CRAMP, Sue; GB
Agents
  • HUHN, Michael; Isenbruck Bösl Hörschler Wichmann Huhn Theodor-Heuss-Anlage 12 68165 Mannheim, DE
Priority Data
06101510.310.02.2006EP
06114491.124.05.2006EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
(FR) COMPOSÉS D'AMINO PYRIMIDINE D'AZÉTIDINE DESTINÉS À TRAITER DES TROUBLES INFLAMMATOIRES
Abstract
(EN)
The present invention relates to novel azetidine amino pyrimidine compounds of formula (I) for the modulation of the histamine H4 receptor and the treatment or prevention of conditions mediated by the histamine H4 receptor. The invention also relates to the preparation of such compounds.
(FR)
L'invention concerne de nouveaux composés d'amino pyrimidine d'azétidine de formule (I) destinés à moduler le récepteur H4 de l'histamine. Ces composés sont destinés à traiter ou à prévenir des troubles médiés par le récepteur H4 de l'histamine. L'invention concerne également la préparation de tels composés.
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