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1. (WO2007090796) THE USE OF NATRIURETIC PEPTIDES AND PLACENTA GROWTH FACTOR LEVELS FOR RISK STRATIFICATION OF INDIVIDUALS ELECTED FOR CARDIAC STRESS TESTING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/090796    International Application No.:    PCT/EP2007/051027
Publication Date: 16.08.2007 International Filing Date: 02.02.2007
Chapter 2 Demand Filed:    06.12.2007    
IPC:
G01N 33/68 (2006.01), G01N 33/50 (2006.01)
Applicants: F. HOFFMANN LA-ROCHE AG [CH/CH]; Grenzacher Strasse 124 CH-4070 Basel (CH) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Strasse 116, 68305 Mannheim (DE) (DE only).
HESS, Georg [DE/DE]; (DE) (For US Only).
HORSCH, Andrea [DE/DE]; (DE) (For US Only)
Inventors: HESS, Georg; (DE).
HORSCH, Andrea; (DE)
Agent: HUHN, Michael; Isenbruck Bösl Hörschler Wichmann Huhn Patentanwälte Theodor-Heuss-Anlage 12 68165 Mannheim (DE)
Priority Data:
06101338.9 06.02.2006 EP
Title (EN) THE USE OF NATRIURETIC PEPTIDES AND PLACENTA GROWTH FACTOR LEVELS FOR RISK STRATIFICATION OF INDIVIDUALS ELECTED FOR CARDIAC STRESS TESTING
(FR) UTILISATION DES TAUX DE PEPTIDES NATRIURÉTIQUES ET DE FACTEUR DE CROISSANCE PLACENTAIRE POUR ÉVALUER LE RISQUE ENCOURRU PAR DES INDIVIDUS APPELÉS À SUBIR UNE ÉPREUVE D'EFFORT CARDIAQUE
Abstract: front page image
(EN)The present invention relates to a method for determining a risk whether an individual will suffer from a cardiovascular adverse event as a consequence of cardiac stress testing, comprising the steps of (a) measuring, preferably in vitro, the level of Placenta Growth Factor, wherein (b) if the level of the Placenta Growth Factor is at least increased, then the individual is at least at risk of suffering from an adverse event as a consequence of cardiac stress testing. In a further embodiment, additionally another marker is measured, particularly a natriuretic peptide, most particularly NT-proBNP. The present invention allows to stratify patients according to the environment and conditions under which cardiac stress testing should be carried out.
(FR)La présente invention concerne un procédé de détermination du risque qu'un individu subisse un événement cardiovasculaire indésirable suite à une épreuve d'effort cardiaque, comprenant (a) la mesure, de préférence in vitro, du taux de facteur de croissance placentaire; (b) si le taux de facteur de croissance placentaire est au moins augmenté, l'individu risque de subir un événement indésirable suite à l'épreuve d'effort cardiaque. Selon un autre mode de réalisation, on mesure en plus un autre marqueur, en particulier un peptide natriurétique, plus particulièrement le NT-proBNP. La présente invention permet d'évaluer les patients en fonction de l'environnement et des conditions dans lesquelles l'épreuve d'effort cardiaque doit avoir lieu.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)