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1. (WO2007089870) VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/089870    International Application No.:    PCT/US2007/002704
Publication Date: 09.08.2007 International Filing Date: 31.01.2007
IPC:
A61K 39/00 (2006.01), C08G 69/26 (2006.01)
Applicants: MEDIVAS, LLC [US/US]; 6275 Nancy Ridge Drive, Suite 103, San Diego, CA 92121 (US) (For All Designated States Except US).
TURNELL, William [GB/US]; (US) (For US Only).
DEFIFE, Kristin [US/US]; (US) (For US Only).
VITIELLO, Maria, A. [IT/US]; (US) (For US Only)
Inventors: TURNELL, William; (US).
DEFIFE, Kristin; (US).
VITIELLO, Maria, A.; (US)
Agent: HAILE, Lisa. J.D.; Ph.D; Dla Piper Us LLP, 4365 Executive Drive, Suite 1100, San Diego, CA 92121-2133 (US)
Priority Data:
11/345,021 31.01.2006 US
PCT/US2006/003412 31.01.2006 US
PCT/US2006/003575 31.01.2006 US
11/344,689 31.01.2006 US
11/345,815 01.02.2006 US
60/842,423 05.09.2006 US
60/858,173 10.11.2006 US
11/636,230 07.12.2006 US
Title (EN) VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE
(FR) COMPOSITIONS DES MODES D'ADMINISTRATION D'UN VACCIN ET PROCEDES D'UTILISATION
Abstract: front page image
(EN)The present invention provides synthetic vaccines against a variety of pathogenic organisms and tumor cells in humans and other mammals based on biodegradable polymers containing polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) and immunostimulatory adjuvants. The vaccines can be formulated as a liquid dispersion of polymer particles or molecules in which are dispersed an immunostimulatory adjuvant, such as a TLR agonist, and whole protein or peptidic antigens containing MHC class I or class II epitopes derived from organism or tumor cell proteins. Methods of inducing an immune response via intracellular mechanisms to the pathogenic organism or tumor cells specific for the antigen in the invention compositions are also included.
(FR)La présente invention concerne des vaccins synthétiques contre une multitude d'organismes pathogènes et des cellules cancéreuses chez des humains et autres mammifères, reposant sur des polymères biodégradables contenant du polyesteramide (PEA), du polyesteruréthane (PEUR), et de la polyester-urée (PEU) et des adjuvants immunostimulants. Les vaccins peuvent être composés sous la forme d'une dispersion liquide de particules polymères ou de molécules dans laquelle sont dispersés un adjuvant immunostimulant, tel qu'un agoniste de TLR, et des antigènes protéiniques ou peptidiques entiers contenant des épitopes MHC classe I ou classe II dérivés de protéines de cellules cancéreuses ou d'organismes. L'invention concerne également des procédés d'induction d'une réponse immunitaire via des mécanismes intracellulaires à un organisme pathogène ou à des cellules cancéreuses spécifiques à l'antigène entrant dans les compositions de l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)