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1. (WO2007089805) ANTI-HYPERTROPHIC EFFECTS AND INOTROPIC EFFECTS OF PICOT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/089805    International Application No.:    PCT/US2007/002583
Publication Date: 09.08.2007 International Filing Date: 30.01.2007
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/00 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street, Boston, MA 02114 (US) (For All Designated States Except US).
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY [KR/KR]; 1 Oryong-dong, Buk-gu, Gwangju 500-712 (KR) (For All Designated States Except US).
HAJJAR, Roger, J. [US/US]; (US) (For US Only).
PARK, Woojin [KR/KR]; (KR) (For US Only)
Inventors: HAJJAR, Roger, J.; (US).
PARK, Woojin; (KR)
Agent: LEAHY, Amy, M.; Edwards Angell Palmer & Dodge LLP, P.O. Box 55874, Boston, MA 02205 (US)
Priority Data:
60/763,515 31.01.2006 US
Title (EN) ANTI-HYPERTROPHIC EFFECTS AND INOTROPIC EFFECTS OF PICOT
(FR) EFFETS ANTI-HYPERTROPHIQUES ET EFFETS INOTROPIQUES D'UNE PICOT
Abstract: front page image
(EN)Expression of protein kinase C-interacting cousin of thioredoxin (PICOT) in heart cells can be used to treat heart failure. PICOT's upregulation in response to hypertrophic stimuli suggests that the putative protein kinase C (PKC) inhibitor constitutes a negative feedback circuit.
(FR)L'invention concerne l'expression d'une cousine de la thiorédoxine interagissant avec la protéine kinase C(PICOT), dans des cellules cardiaques, pouvant être utilisée pour traiter une insuffisance cardiaque. La régulation à la hausse de la PICOT en réponse à des stimulus hypertrophiques suggère que l'inhibiteur putatif de la protéine kinase C (PKC) constitue un circuit de rétroaction négative.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)