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Machine translation
1. (WO2007089768) 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/089768    International Application No.:    PCT/US2007/002515
Publication Date: 09.08.2007 International Filing Date: 30.01.2007
IPC:
C07D 239/42 (2006.01), C07D 401/04 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 405/04 (2006.01), C07D 405/12 (2006.01), C07D 405/14 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 413/04 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 453/02 (2006.01), C07D 487/04 (2006.01)
Applicants: EXELIXIS, INC. [US/US]; Post Office Box 511, 210 East Grand Avenue, South San Francisco, CA 94083-0511 (US) (For All Designated States Except US).
MANN, Grace [US/US]; (US) (For US Only).
AAY, Naing [US/US]; (US) (For US Only).
ARCALAS, Arlyn [US/US]; (US) (For US Only).
BROWN, S. David [US/US]; (US) (For US Only).
CHAN, Wai Ki Vicky [US/US]; (US) (For US Only).
CHEN, Jeff [US/US]; (US) (For US Only).
DU, Hongwang [CN/US]; (US) (For US Only).
EPSHTEYN, Sergey [US/US]; (US) (For US Only).
FORSYTH, Timothy, Patrick [US/US]; (US) (For US Only).
GALAN, Adam A. [US/US]; (US) (For US Only).
HUYNH, Tai Phat [US/US]; (US) (For US Only).
IBRAHIM, Mohamed Abdulkader [US/US]; (US) (For US Only).
JOHNSON, Henry William Beecroft [US/US]; (US) (For US Only).
KANE, Brian [US/US]; (US) (For US Only).
KEARNEY, Patrick [US/US]; (US) (For US Only).
KIM, Byung Gyu [KR/US]; (US) (For US Only).
KOLTUN, Elena, S. [RU/US]; (US) (For US Only).
LEAHY, James, W. [US/US]; (US) (For US Only).
LEE, Matthew Sangyup [US/US]; (US) (For US Only).
LEWIS, Gary L. [US/US]; (US) (For US Only).
MEYR, Lisa, E. [US/US]; (US) (For US Only).
NOGUCHI, Robin Tammie [US/US]; (US) (For US Only).
PACK, Michael [US/US]; (US) (For US Only).
RIDGWAY, Brian Hugh [US/US]; (US) (For US Only).
SHI, Xian [CN/US]; (US) (For US Only).
WOOLFREY, John [US/US]; (US) (For US Only).
ZHOU, Peiwen [CN/US]; (US) (For US Only)
Inventors: MANN, Grace; (US).
AAY, Naing; (US).
ARCALAS, Arlyn; (US).
BROWN, S. David; (US).
CHAN, Wai Ki Vicky; (US).
CHEN, Jeff; (US).
DU, Hongwang; (US).
EPSHTEYN, Sergey; (US).
FORSYTH, Timothy, Patrick; (US).
GALAN, Adam A.; (US).
HUYNH, Tai Phat; (US).
IBRAHIM, Mohamed Abdulkader; (US).
JOHNSON, Henry William Beecroft; (US).
KANE, Brian; (US).
KEARNEY, Patrick; (US).
KIM, Byung Gyu; (US).
KOLTUN, Elena, S.; (US).
LEAHY, James, W.; (US).
LEE, Matthew Sangyup; (US).
LEWIS, Gary L.; (US).
MEYR, Lisa, E.; (US).
NOGUCHI, Robin Tammie; (US).
PACK, Michael; (US).
RIDGWAY, Brian Hugh; (US).
SHI, Xian; (US).
WOOLFREY, John; (US).
ZHOU, Peiwen; (US)
Agent: BERNSTEIN, Robert L.; EXELIXIS, Inc., 210 East Grand Avenue Post Office Box 511, South San Francisco, CA 94083-0511 (US)
Priority Data:
60/763,426 30.01.2006 US
60/785,239 23.03.2006 US
60/840,420 25.08.2006 US
Title (EN) 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
(FR) 4-ARYL-2-AMINO-PYRIMIDINES OU 4-ARYL-2-AMINOALKYL-PYRIMIDINES UTILISÉES COMME MODULATEURS DE LA JAK-2 ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
(FR)La présente invention concerne certains inhibiteurs de la JAK-2, dérivés de la pyrimidine, de la formule (I) : D, E, L, Z, R1, R2, R25 et n1 étant tels que définis dans la description, des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques de ceux-ci et leurs procédés d'utilisation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)