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1. WO2007089745 - NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX

Publication Number WO/2007/089745
Publication Date 09.08.2007
International Application No. PCT/US2007/002475
International Filing Date 29.01.2007
IPC
C07C 229/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
CPC
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61K 47/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
542Carboxylic acids, e.g. a fatty acid or an amino acid
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07C 229/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
08the nitrogen atom of the amino group being further bound to hydrogen atoms
C07C 229/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
22the carbon skeleton being further substituted by oxygen atoms
Applicants
  • SIGNATURE R & D HOLDINGS, LLC [US]/[US] (AllExceptUS)
  • CHANDRAN, V., Ravi [US]/[US] (UsOnly)
Inventors
  • CHANDRAN, V., Ravi
Agents
  • GROLZ, Edward, W.
Priority Data
11/343,55730.01.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX
(FR) NOUVEAUX COMPOSÉS À INDICE THÉRAPEUTIQUE ÉLEVÉ
Abstract
(EN)
The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These high therapeutic index derivatives have the same utility as the drug from which they are made, and they have enhanced pharmacological and pharmaceutical properties. In fact, the novel drug derivatives of the present invention enhance at least one therapeutic quality, as defined herein. The present invention is also directed to pharmaceutical compositions containing same.
(FR)
La présente invention concerne de nouveaux composés thérapeutiques constitués d'un acide aminé lié à un médicament possédant un dérivé hydroxy, amino, carboxy ou d'acylation. Ces dérivés à indice thérapeutique élevé ont la même utilité que le médicament à partir duquel ils sont fabriqués et ils présentent de meilleures propriétés pharmacologiques et pharmaceutiques. En fait, les nouveaux dérivés du médicament de cette invention améliorent au moins une qualité thérapeutique, comme cela est décrit ici. L'invention a aussi pour objet des compositions pharmaceutiques contenant lesdits composés.
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