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1. WO2007089601 - NOGO RECEPTOR ANTAGONISTS

Publication Number WO/2007/089601
Publication Date 09.08.2007
International Application No. PCT/US2007/002199
International Filing Date 26.01.2007
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A01K 2217/058
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
054inducing loss of function
058due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/0356
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
035Animal model for multifactorial diseases
0356Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A01K 67/0275
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
Applicants
  • BIOGEN IDEC MA INC. [US]/[US] (AllExceptUS)
  • LEE, Daniel, H.S. [US]/[US] (UsOnly)
  • WEN, Dingyi [US]/[US] (UsOnly)
  • PEPINSKY, R., Blake [US]/[US] (UsOnly)
  • RELTON, Jane, K. [GB]/[US] (UsOnly)
  • WANG, Xinzhong [US]/[US] (UsOnly)
  • LUGOVSKOY, Alexey [RU]/[US] (UsOnly)
  • MEIER, Werner [CH]/[US] (UsOnly)
  • GARBER, Ellen, A. [US]/[US] (UsOnly)
  • SILVIAN, Laura [US]/[US] (UsOnly)
  • WEINREB, Paul, H. [US]/[US] (UsOnly)
Inventors
  • LEE, Daniel, H.S.
  • WEN, Dingyi
  • PEPINSKY, R., Blake
  • RELTON, Jane, K.
  • WANG, Xinzhong
  • LUGOVSKOY, Alexey
  • MEIER, Werner
  • GARBER, Ellen, A.
  • SILVIAN, Laura
  • WEINREB, Paul, H.
Agents
  • HAANES, Elizabeth, J.
Priority Data
60/762,48727.01.2006US
60/831,65919.07.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOGO RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DES RÉCEPTEURS NOGO
Abstract
(EN)
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
(FR)
L'invention concerne des polypeptides immunogènes du récepteur 1 Nogo, des anticorps dirigés contre le récepteur 1 Nogo, des fragments de liaison antigénique de ceux-ci, des récepteurs Nogo solubles et des protéines de fusion de ces récepteurs, ainsi que des acides nucléiques codant pour ces récepteurs. L'invention concerne également des polynucléotides antagonistes des récepteurs Nogo. Elle concerne également des compositions comprenant lesdits anticorps dirigés contre les récepteurs Nogo, fragments de liaison antigénique de ceux-ci, récepteurs Nogo solubles et protéines de fusion de ces récepteurs, acides nucléiques codant pour ces récepteurs et polynucléotides antagonistes, ainsi que des procédés pour les produire et les utiliser.
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