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1. WO2007089101 - NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Publication Number WO/2007/089101
Publication Date 09.08.2007
International Application No. PCT/KR2007/000533
International Filing Date 31.01.2007
IPC
C07D 277/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
22with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A61K 31/426 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
A61K 31/155 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
A61P 19/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
CPC
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
C07D 277/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
22with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
28Radicals substituted by nitrogen atoms
C07D 417/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • DONG WHA PHARMACEUTICAL IND.CO., LTD. [KR]/[KR] (AllExceptUS)
  • RYU, Jei Man [KR]/[KR] (UsOnly)
  • LEE, Jin Soo [KR]/[KR] (UsOnly)
  • JIN, Young Goo [KR]/[KR] (UsOnly)
  • LEE, Ki Young [KR]/[KR] (UsOnly)
  • PARK, Jae Hoon [KR]/[KR] (UsOnly)
  • HWANG, Yun Ha [KR]/[KR] (UsOnly)
  • KU, Sae Kwang [KR]/[KR] (UsOnly)
Inventors
  • RYU, Jei Man
  • LEE, Jin Soo
  • JIN, Young Goo
  • LEE, Ki Young
  • PARK, Jae Hoon
  • HWANG, Yun Ha
  • KU, Sae Kwang
Agents
  • SON, Min
Priority Data
10-2006-000945931.01.2006KR
Publication Language English (EN)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
(FR) NOUVEAUX DÉRIVÉS DE BENZAMIDINE, PROCÉDÉ DE FABRICATION ET COMPOSITION PHARMACEUTIQUE LES RENFERMANT
Abstract
(EN)
The present invention relates to a novel benzamidine derivative, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzamidine derivative of the present invention effectively inhibits osteoclast differentiation at an extremely low concentration, and greatly increases the trabecular bone volume, and thus it can be advantageously used for the prevention and treatment of osteoporosis.
(FR)
L'invention concerne un nouveau dérivé de benzamidine, son procédé de fabrication et une composition pharmaceutique le renfermant. Même en très faible concentration, ce dérivé de benzamidine inhibe efficacement la différentiation des ostéoclastes et accroît considérablement le volume osseux trabéculaire. Il peut, ipso facto, s'utiliser avantageusement pour la prévention et le traitement de l'ostéoporose.
Latest bibliographic data on file with the International Bureau