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1. WO2007088545 - NOVEL PROCESS FOR PREPARING 1-(MERCAPTOMETHYL) CYCLOPROPANEACETIC ACID, A USEFUL INTERMEDIATE IN THE PREPARATION OF MONTELUKAST AND SALTS THEREOF

Publication Number WO/2007/088545
Publication Date 09.08.2007
International Application No. PCT/IL2007/000133
International Filing Date 01.02.2007
Chapter 2 Demand Filed 31.08.2007
IPC
C07C 337/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
337Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/ or C07C335/141
CPC
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 319/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
319Preparation of thiols, sulfides, hydropolysulfides or polysulfides
02of thiols
C07C 335/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
335Thioureas, i.e. compounds containing any of the groups , the nitrogen atoms not being part of nitro or nitroso groups
30Isothioureas
32having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
C07D 215/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Halogen atoms or nitro radicals
Applicants
  • CHEMAGIS LTD. [IL]/[IL] (AllExceptUS)
  • WANG, Yanling [CN]/[CN] (UsOnly)
  • WANG, Yuang [CN]/[CN] (UsOnly)
  • BRAND, Michael [IL]/[IL] (UsOnly)
  • KASPI, Joseph [IL]/[IL] (UsOnly)
Inventors
  • WANG, Yanling
  • WANG, Yuang
  • BRAND, Michael
  • KASPI, Joseph
Agents
  • G. E. EHRLICH (1995) LTD.
Priority Data
60/764,34702.02.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL PROCESS FOR PREPARING 1-(MERCAPTOMETHYL) CYCLOPROPANEACETIC ACID, A USEFUL INTERMEDIATE IN THE PREPARATION OF MONTELUKAST AND SALTS THEREOF
(FR) NOUVEAU PROCÉDÉ POUR LA PRÉPARATION DE L'ACIDE 1-[(MERCAPTOMÉTHYL)CYCLOPROPANE]ACÉTIQUE, UN INTERMÉDIAIRE UTILE DANS LA PRÉPARATION DE MONTELUKASTE ET DES SES SELS
Abstract
(EN)
The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.
(FR)
La présente invention concerne un nouvel intermédiaire de montelukaste et un procédé simple et pratique pour sa préparation. Selon la présente invention, grâce à l'utilisation de cet intermédiaire et du procédé, tels que décrits dans la spécification, on obtient un acide de montélukaste et ses sels.
Also published as
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