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Machine translation
1. (WO2007088528) MICROTUBULE TARGETING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/088528    International Application No.:    PCT/IE2007/000011
Publication Date: 09.08.2007 International Filing Date: 02.02.2007
Chapter 2 Demand Filed:    20.07.2007    
IPC:
A61K 31/553 (2006.01), A61K 31/554 (2006.01), A61P 9/00 (2006.01), A61P 9/08 (2006.01), A61P 33/06 (2006.01)
Applicants: THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN [IE/IE]; Trinity College, Dublin University, Dublin 2 (IE) (For All Designated States Except US).
ZISTERER, Daniela [IE/IE]; (IE) (For US Only).
WILLIAMS, David, Clive [GB/IE]; (IE) (For US Only).
MULLIGAN, Jude [IE/IE]; (IE) (For US Only)
Inventors: ZISTERER, Daniela; (IE).
WILLIAMS, David, Clive; (IE).
MULLIGAN, Jude; (IE)
Agent: GATES, Marie, Christina, Esther; Tomkins & Co., 5 Dartmouth Road, Dublin 6 (IE)
Priority Data:
S2006/0066 03.02.2006 IE
Title (EN) MICROTUBULE TARGETING AGENTS
(FR) AGENTS DE CIBLAGE DE MICROTUBULES
Abstract: front page image
(EN)The present invention provides for the use of a compound having the general formula (I), wherein: (i) A represents O or S; (ii) the cyclic group labelled F represents a benzyl group, a 2,3-naphthyl group or a benzyl group substituted with ethoxycarbonyl at the 2-position; (iii) and Y represents N(CH3)2, NHCH3, CH3 or pyridine; as an agent for one or more of the group consisting of an attenuating microtubule growth, depolymerising microtubules, arresting G2/M transition, activation of CDK1 activity, treatment of coronary heart disease, treatment of restenosis, treatment of arteriosclerosis and treatment of malaria.
(FR)L'invention concerne l'utilisation d'un composé représenté par la formule générale (I), dans laquelle: (i) A représente O ou S; (ii) le groupe cyclique désigné F représente un groupe benzyle, un groupe 2,3-naphtyle ou un groupe benzyle substitué par éthoxycarbonyle en position 2; (iii) Y représente N(CH3)2, NHCH3, CH3 ou pyridine; en tant qu'agent d'un ou plusieurs du groupe consistant en l'atténuation de la croissance de microtubules, la dépolymérisation de microtubules, l'arrêt de la transition de G2/M, l'activation de CDK1, le traitement de la maladie cardiaque coronarienne, le traitement de la resténose, le traitement de l'athérosclérose et le traitement de la malaria.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)