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1. WO2007088473 - TREATMENT AND PREVENTION OF DEPRESSION WITH PAIN, DEPRESSION SECONDARY TO PAIN, AND OF NEUROPATHIC PAIN

Publication Number WO/2007/088473
Publication Date 09.08.2007
International Application No. PCT/IB2007/000248
International Filing Date 01.02.2007
IPC
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 25/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
Applicants
  • NEUROCURE LTD [IE]/[IE] (AllExceptUS)
  • DINAN, Timothy [IE]/[IE] (UsOnly)
Inventors
  • DINAN, Timothy
Agents
  • EVENS, Paul, Jonathan
Priority Data
60/765,24503.02.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT AND PREVENTION OF DEPRESSION WITH PAIN, DEPRESSION SECONDARY TO PAIN, AND OF NEUROPATHIC PAIN
(FR) TRAITEMENT ET PRÉVENTION DE LA DÉPRESSION AVEC DOULEURS, DE LA DÉPRESSION INDUITE PAR DES DOULEURS ET DE DOULEURS NEUROPATHIQUES
Abstract
(EN)
In accordance with the present invention, it has been discovered that compounds exhibiting activity as a potent noradrenaline reuptake inhibitor (e.g., a NA: 5HT ratio of greater than or equal to about 1000:1), and activity at the dopamine D2 receptor sites (e.g., lofeprarnine) are effective in the treatment and prevention of various diseases and disorders associated with noradrenaline reuptake, such as pain predominant-type depression, depression secondary to chronic or neuropathic pain, and neuropathic pain itself.
(FR)
L'invention concerne des composés possédant une activité comme inhibiteurs du recaptage de la noradrénaline puissants (par exemple, un rapport NA: 5HT supérieur ou égal à environ 1000:1) et une activité au niveau des sites des récepteurs D2 de la dopamine D2 (par exemple, la lofeprarnine), ces composés étant efficaces dans le traitement et la prévention de diverses maladies et divers troubles associés au recaptage de la noradrénaline, tels qu'une dépression du type à douleurs prédominantes, une dépression induite par des douleurs chroniques ou neuropathiques et des douleurs neuropathiques.
Also published as
Latest bibliographic data on file with the International Bureau