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1. (WO2007088099) COMPOUNDS FOR THE TREATMENT OF ISCHEMIA AND NEURODEGENERATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/088099    International Application No.:    PCT/EP2007/050364
Publication Date: 09.08.2007 International Filing Date: 15.01.2007
IPC:
A61K 38/06 (2006.01), A61P 25/00 (2006.01), A61P 9/00 (2006.01)
Applicants: ONCOREG AB [SE/SE]; Fogdevreten 2B, S-171 77 Stockholm (SE) (For All Designated States Except US).
GLAS, Rickard [SE/SE]; (SE) (For US Only).
XU, Hong [CN/SE]; (SE) (For US Only)
Inventors: GLAS, Rickard; (SE).
XU, Hong; (SE)
Agent: GREGORY, Robert, J., H.; W.P. Thompson & Co., Coopers Building,, Church Street, Liverpool Merseyside L1 3AB (GB)
Priority Data:
60/759,088 13.01.2006 US
Title (EN) COMPOUNDS FOR THE TREATMENT OF ISCHEMIA AND NEURODEGENERATION
(FR) COMPOSES SERVANT À TRAITER UNE ISCHÉMIE ET UNE NEURODÉGÉNÉRATION
Abstract: front page image
(EN)TPP II (tripeptidyl peptidase II) inhibitors are useful in the treatment of a neurodegenerative disease, for example Alzheimer's, Parkinson's or Huntingdon's disease or an ischemic condition, for example stroke and cardiac infarction. Suitable compounds comprise tripeptide compounds of general formula RN1RN2N-A1-A2-A3-CO-RC1 wherein RN1, RN2, A1, A2, A3 and RC1 are as defined herein, and which include for example the tripeptide sequences GLA and GPG.
(FR)L'invention concerne des inhibiteurs de TPP II (tripeptidyle peptidase II) servant à traiter une maladie neurodégénérative, par exemple la maladie d'Alzheimer, de Parkinson ou de Huntingdon, ou un trouble ischémique, par exemple un accident vasculaire cérébral et un infarcissement cardiaque. Des composés appropriés de l'invention comprennent des composés tripeptidiques de formule RN1RN2N-A1-A2-A3-CO-RC1. Dans cette formule, RN1, RN2, A1, A2, A3 et RC1 sont définis dans la description et comprennent, par exemple, des séquences tripeptidiques GLA et GPG.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)