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1. (WO2007087700) PROCESS FOR THE PREPARATION OF FORMULATIONS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND PRODUCT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/087700    International Application No.:    PCT/BR2007/000025
Publication Date: 09.08.2007 International Filing Date: 05.02.2007
IPC:
A61K 47/40 (2006.01), A61K 31/401 (2006.01)
Applicants: UNIVERSIDADE FEDERAL DE MINAS GERAIS [BR/BR]; Av. Antonio Carlos, 6627 - Pampulha, Belo Horizonte-Minas Gerais, Brazil (BR) (For All Designated States Except US).
STQ COMÉRCIO E SERVICIOS DE TECNOLOGIA QUÍMICAL LTDA. [BR/BR]; Av. Prof. Lineu Prestes, 2242, Cidade Universitári, a, 05508-000-São Paulo - SP (BR) (For All Designated States Except US).
DE BURGOS MARTINS DE AZEVEDO, Mariangela [BR/BR]; (BR) (For US Only)
Inventors: DE BURGOS MARTINS DE AZEVEDO, Mariangela; (BR)
Agent: DANNEMANN, SIEMSEN, BIGLER & IPANEMA MOREIRA; Caixa Postal 2142, Rua Marquês de Olinda, 70, Botafogo, CEP-22251-040 Rio de Janeiro, RJ (BR)
Priority Data:
PI0600636-1 03.02.2006 BR
Title (EN) PROCESS FOR THE PREPARATION OF FORMULATIONS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND PRODUCT
(FR) PROCÉDÉ DE PRÉPARATION DE FORMULATIONS D'INHIBITEURS DE L'ENZYME DE CONVERSION DE L'ANGIOTENSINE ET PRODUIT
Abstract: front page image
(EN)The process for the preparation of formulations of angiotensin converting enzyme inhibitors and product is directed to obtaining a modified release system of an angiotensin converting enzyme (ACE) inhibitor, preferably captopril, from its molecular inclusion in natural cyclodextrins, preferably β-cyclodextrins, and/or alkyl and acyl derivatives thereof, using an aqueous and/or organic solvent medium. The product thus obtained has reduced solubility and chemical instability of the active principle, enhancing the therapeutic action results.
(FR)L'invention concerne un procédé de préparation de formulations d'inhibiteurs de l'enzyme de conversion de l'angiotensine et un produit qui permet d'obtenir un système à libération modifiée d'un inhibiteur de l'enzyme de conversion de l'angiotensine ('angiotensin converting enzyme' ou ACE), de préférence du captopril, à partir de son inclusion moléculaire dans des cyclodextrines naturelles, de préférence des β-cyclodextrines, et/ou des dérivés alkyle et acyle de ces dernières, en utilisant un milieu solvant aqueux et/ou organique. Le produit obtenu présente un principe actif dont la solubilité et l'instabilité chimique sont réduites, améliorant de la sorte les résultats de l'action thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)