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1. (WO2007087506) COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/087506    International Application No.:    PCT/US2007/060833
Publication Date: 02.08.2007 International Filing Date: 22.01.2007
IPC:
A01N 35/00 (2006.01), A61K 31/12 (2006.01), A61K 31/075 (2006.01)
Applicants: WELLSTAT THERAPEUTICS CORPORATION [--/US]; 930 Clopper Road, Gaithersburg, MD 20878 (US) (For All Designated States Except US).
SHARMA, Shalini [US/US]; (US) (For US Only).
VON BORSTEL, Reid, W. [US/US]; (US) (For US Only)
Inventors: SHARMA, Shalini; (US).
VON BORSTEL, Reid, W.; (US)
Agent: KREISLER, Lewis, J.; LEGAL DEPARTMENT, 930 Clopper Road, Gaithersburg, MD 20878 (US)
Priority Data:
60/762,068 25.01.2006 US
Title (EN) COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
(FR) COMPOSÉS DESTINÉS AU TRAITEMENT DES TROUBLES DU MÉTABOLISME
Abstract: front page image
(EN)Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I), wherein n is 1 or 2; m is 0, 1, 2, 3, or 4; q is 0 or 1; t is 0 or 1; R1 is hydrogen, halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; R2 is alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; one of R4 and R5 is hydrogen or hydroxy and the other is hydrogen; or R4 and R5 together arc =O; R6 is hydrogen or alkyl having one, two, three, four or five carbon atoms; or a pharmaceutically acceptable salt of the compound. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula (I).
(FR)L'invention concerne des agents convenant pour le traitement de divers troubles du métabolisme tels que: syndrome de résistance à l'insuline, diabète, syndrome de Stein-Leventhal, hyperlipidémie, stéatose hépatique, cachexie, obésité, athérosclérose ou artériosclérose.(...). Ces agents sont représentés par la formule (I) dans laquelle n vaut 1 ou 2; m vaut 0, 1,2, 3 ou 4; q vaut 0 ou 1; t vaut 0 ou 1; R1est hydrogène, halo, hydroxy, alkyle à 1 ou 2 atomes de carbone, et perfluorométhoxy; R2 est un alkyle à 1-3 atomes de carbone, ou un alkoxy à 1-3 atomes de carbone; R3 est hydrogène, halo, alkyle à 1-3 atomes d e carbone ou un alkoxy à 1-3 àtomes de carbone. L'un de R4 et de R5 est hydrogène ou hydroxy, l'autre est hydrogène; ou bien R4 et R5 ensemble = O; R6 est hydrogène ou un alkyle comptant un, deux, trois, quatre ou cinq altomes de carbone; ou bien un sel pharmacocompatible du composé de formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)