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Machine translation
1. (WO2007087224) HEXAHYDRO-3H-PYRROLIZIN-3-ONES USEFUL AS TACHYKININ RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/087224    International Application No.:    PCT/US2007/001375
Publication Date: 02.08.2007 International Filing Date: 19.01.2007
IPC:
A61K 31/497 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
BAO, Jianming [US/US]; (US) (For US Only).
DEVITA, Robert, J. [US/US]; (US) (For US Only).
LU, Huagang [CN/US]; (US) (For US Only).
MILLS, Sander, G. [US/US]; (US) (For US Only).
MORRIELLO, Gregori, J. [US/US]; (US) (For US Only)
Inventors: BAO, Jianming; (US).
DEVITA, Robert, J.; (US).
LU, Huagang; (US).
MILLS, Sander, G.; (US).
MORRIELLO, Gregori, J.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/761,622 24.01.2006 US
Title (EN) HEXAHYDRO-3H-PYRROLIZIN-3-ONES USEFUL AS TACHYKININ RECEPTOR ANTAGONISTS
(FR) HEXAHYDRO-3H-PYRROLIZIN-3-ONES UTILES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE LA TACHYKININE
Abstract: front page image
(EN)The present invention is directed to certain hexahydroyrrolidinone compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
(FR)La présente invention concerne certains composés hexahydroyrrolidinone qui sont utiles en tant qu'antagonistes du récepteur de la neurokinine-1 (NK-1) et des inhibiteurs de la tachykinine, notamment la substance P. Cette invention porte également sur des compositions pharmaceutiques qui comprennent ces composés en tant qu'ingrédients actifs et sur l'utilisation de ces composés et de leurs formulations dans le traitement de certaines maladies ou troubles tels que les vomissements, l'incontinence urinaire, la dépression et l'anxiété.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)