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1. (WO2007086541) PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/086541    International Application No.:    PCT/JP2007/051334
Publication Date: 02.08.2007 International Filing Date: 23.01.2007
IPC:
A61K 47/14 (2006.01), A61K 47/10 (2006.01), A61K 9/48 (2006.01), A61K 31/352 (2006.01)
Applicants: R-TECH UENO, LTD. [JP/JP]; 1-7, Uchisaiwai-cho 1-chome, Chiyoda-ku, Tokyo, 1000011 (JP) (For All Designated States Except US).
HIRATA, Ryu [JP/JP]; (JP) (For US Only).
HARADA, Yasuhiro [JP/JP]; (JP) (For US Only).
UENO, Ryuji [JP/US]; (US) (For US Only)
Inventors: HIRATA, Ryu; (JP).
HARADA, Yasuhiro; (JP).
UENO, Ryuji; (US)
Agent: TANAKA, Mitsuo; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001 (JP)
Priority Data:
60/761,362 24.01.2006 US
Title (EN) PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT UN COMPOSÉ BICYCLIQUE ET PROCÉDÉ POUR STABILISER CE COMPOSÉ BICYCLIQUE
Abstract: front page image
(EN)Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I), comprising the step of : admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
(FR)L'invention concerne un procédé pour stabiliser un composé bicyclique pharmaceutiquement actif représenté par la formule (I), ce procédé consistant à mélanger ledit composé avec un polyol et/ou un ester d'acide gras autre qu'un glycéride, ainsi qu'une composition obtenue par ce procédé. L'invention concerne également une formulation de capsule molle à base du composé de formule (I) obtenu par incorporation dudit composé dans une enveloppe de capsule molle comprenant de la gélatine et un plastifiant sous forme de polyol.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)