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1. (WO2007086526) GENE POLYMORPHISM AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/086526    International Application No.:    PCT/JP2007/051309
Publication Date: 02.08.2007 International Filing Date: 26.01.2007
IPC:
C12N 15/09 (2006.01), A61K 31/7088 (2006.01), A61K 39/395 (2006.01), A61K 48/00 (2006.01), A61P 35/00 (2006.01), C12Q 1/68 (2006.01), C07K 16/18 (2006.01)
Applicants: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY [JP/JP]; Nu 7, Kakuma-machi, Kanazawa-shi, Ishikawa 9201164 (JP) (For All Designated States Except US).
HIGASHI, Tomomi [JP/JP]; (JP) (For US Only).
SAIJO, Kiyofumi [JP/JP]; (JP) (For US Only).
KYO, Satoru [JP/JP]; (JP) (For US Only).
INOUE, Masaki [JP/JP]; (JP) (For US Only)
Inventors: HIGASHI, Tomomi; (JP).
SAIJO, Kiyofumi; (JP).
KYO, Satoru; (JP).
INOUE, Masaki; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1 Fushimimachi 4-chome, Chuo-ku Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2006-019859 27.01.2006 JP
Title (EN) GENE POLYMORPHISM AND USE THEREOF
(FR) POLYMORPHISME GÉNIQUE ET SON UTILISATION
(JA) 遺伝子多型およびその用途
Abstract: front page image
(EN)It is intended to provide a method of estimating the prognosis of cancer, in particular, ovary cancer, uterine corpus cancer and lung cancer, by examining a polymorphism (-202G/C and +20A/C) occurring in the 5’-regulatory region of LTBP-1L gene; and a method of treating cancer, in particular, ovary cancer, uterine corpus cancer and lung cancer, by inhibiting the expression or activity of LTBP-1L. It is also intended to provide a method of predicting the sensitivity to uterine corpus cancer, gastric cancer and lung cancer by examining the polymorphism as described above.
(FR)La présente invention concerne un procédé d'estimation du pronostic d'un cancer, en particulier le cancer de l'ovaire, le cancer du corps utérin et le cancer du poumon, en examinant un polymorphisme (-202G/C et +20A/C) qui se produit dans la région régulatrice 5’ du gène LTBP-1L ; et un procédé de traitement d'un cancer, en particulier du cancer de l'ovaire, du cancer du corps utérin et du cancer du poumon, en inhibant l'expression ou l'activité du gène LTBP-1L. La présente invention concerne également un procédé de prédiction de la sensibilité au cancer du corps utérin, au cancer de l'estomac et au cancer du poumon en examinant le polymorphisme décrit ci-dessus.
(JA) 本発明は、LTBP-1L遺伝子の5’-調節領域内に存在する多型(-202G/Cおよび+20A/C)を検定することによる癌、特に卵巣癌、子宮体癌および肺癌の予後診断方法、LTBP-1Lの発現もしくは活性を阻害することによる癌、特に卵巣癌、子宮体癌および肺癌の治療を提供する。  さらに、本発明は、前記多型を検定することによる子宮体癌、胃癌および肺癌に対する感受性の予測方法を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)