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1. (WO2007086471) PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/086471    International Application No.:    PCT/JP2007/051186
Publication Date: 02.08.2007 International Filing Date: 25.01.2007
IPC:
C07D 295/08 (2006.01), A61K 31/40 (2006.01), A61P 5/30 (2006.01), A61P 5/32 (2006.01), A61P 9/00 (2006.01), A61P 15/12 (2006.01), A61P 19/10 (2006.01), A61P 43/00 (2006.01), C07C 41/24 (2006.01), C07C 41/26 (2006.01), C07C 43/23 (2006.01), C07C 67/293 (2006.01), C07C 69/63 (2006.01)
Applicants: TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION [JP/JP]; 1-3, Kagurazaka, Shinjuku-ku, Tokyo 1628601 (JP) (For All Designated States Except US).
SHIINA, Isamu [JP/JP]; (JP) (For US Only).
SANO, Yoshiyuki [JP/JP]; (JP) (For US Only).
NAKATA, Kenya [JP/JP]; (JP) (For US Only)
Inventors: SHIINA, Isamu; (JP).
SANO, Yoshiyuki; (JP).
NAKATA, Kenya; (JP)
Agent: SHOBAYASHI, Masayuki; Takase Bldg. 25-8, Higashi-ikebukuro 1-chome Toshima-ku, Tokyo 1700013 (JP)
Priority Data:
2006-018079 26.01.2006 JP
2007-001114 09.01.2007 JP
Title (EN) PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF
(FR) PROCÉDÉ DE PRODUCTION DE LASOFOXIFÈNE OU D'UN ANALOGUE
(JA) ラソフォキシフェン及びその類縁体の製造方法
Abstract: front page image
(EN)Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue thereof, a compound represented by the formula (4) is used as an intermediate. The compound represented by the formula (4) can be produced using compounds represented by the formulae (1) to (3) as starting compounds by performing the coupling of the three components in one step.
(FR)L'invention concerne un nouveau procédé de production de lasofoxifène, de nafoxidine ou d'un analogue de ces derniers, qui comporte un nombre réduit d'étapes de réaction, qui possède une efficacité élevée et qui offre des avantages pratiques. On utilise, pour produire du lasofoxifène ou un analogue de ce dernier, un composé représenté par la formule (4) comme intermédiaire. On peut produire le composé représenté par la formule (4) en utilisant comme composés de départ les composés représentés par les formules (1) à (3), le couplage des trois composants s'effectuant en une étape.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)