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1. (WO2007086082) A PROCESS FOR MANUFACTURING ROSUVASTATIN POTASSIUM AND CRYSTALLINE AND AMORPHOUS FORMS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/086082    International Application No.:    PCT/IN2007/000037
Publication Date: 02.08.2007 International Filing Date: 25.01.2007
Chapter 2 Demand Filed:    20.08.2007    
IPC:
C07D 239/42 (2006.01), A61K 31/505 (2006.01), A61P 3/06 (2006.01)
Applicants: CADILA HEALTHCARE LIMITED [IN/IN]; Zydus Tower, Satellite Cross Roads, Amedadabad 380 015, Gujarat (IN) (For All Designated States Except US).
PATEL, Dhimant, Jasubhai [IN/IN]; (IN) (For US Only).
KUMAR, Rajiv [IN/IN]; (IN) (For US Only).
AGARWAL, Virendra, Kumar [IN/IN]; (IN) (For US Only)
Inventors: PATEL, Dhimant, Jasubhai; (IN).
KUMAR, Rajiv; (IN).
AGARWAL, Virendra, Kumar; (IN)
Agent: SUBRAMANIAM, Hariharan; Subramaniam, Nataraj & Associates, E 556, Greater Kailash II, New Delhi 110 048 (IN)
Priority Data:
1217/MUM/2005 30.01.2006 IN
Title (EN) A PROCESS FOR MANUFACTURING ROSUVASTATIN POTASSIUM AND CRYSTALLINE AND AMORPHOUS FORMS THEREOF
(FR) PROCEDE DE FABRICATION DU SEL DE POTASSIUM DE LA ROSUVASTATINE
Abstract: front page image
(EN)A process of manufacturing of Rosuvastatin Potassium of formula (1) is disclosed. The process comprises the steps of (a) treating Rosuvastatin protected compound of formula (II) wherein R1 and R2 are same or different having C1-C4 carbon atom or hydrogen or R1 and R2 can combine together to afford a cyclic structure comprising a junction atom as carbon or metal atom such as Si (silicon); with an inorganic base of the kind such as herein described having potassium as cation in a suitable solvent to form Rosuvastatin potassium; (b) isolating Rosuvastatin potassium.
(FR)La présente invention concerne un procédé de fabrication du sel de potassium de la rosuvastatine répondant à la formule (1). Le procédé comprend les étapes consistant à (a) traiter le composé rosuvastatine protégé répondant à la formule (II) dans laquelle R1 et R2 sont identiques ou différents et représentent un groupe ayant de 1 à 4 atomes de carbone ou un atome d’hydrogène ou R1 et R2 peuvent être combinés de façon à former une structure cyclique comprenant un atome de jonction tel qu’un atome de carbone ou d’un métal tel que Si (silicium) ; avec une base inorganique telle que décrite ici ayant le potassium comme cation dans un solvant approprié de façon à former le sel de potassium de la rosuvastatine ; (b) isoler le sel de potassium de la rosuvastatine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)