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1. WO2007086011 - FORMULATION COMPRISING CEFEPIME, TAZOBACTAM AND LINEZOLID

Publication Number WO/2007/086011
Publication Date 02.08.2007
International Application No. PCT/IB2007/050243
International Filing Date 24.01.2007
IPC
A61K 31/546 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
545Compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
546containing further heterocyclic rings, e.g. cephalothin
A61K 31/424 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
424condensed with heterocyclic ring systems, e.g. clavulanic acid
A61K 31/431 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
429condensed with heterocyclic ring systems
43Compounds containing 4-thia-1-azabicyclo heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
431containing further heterocyclic ring systems, e.g. ticarcillin, azlocillin, oxacillin
CPC
A61K 31/424
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
42Oxazoles
424condensed with heterocyclic ring systems, e.g. clavulanic acid
A61K 31/431
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
429condensed with heterocyclic ring systems
43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
431containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
A61K 31/546
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins, ; cefaclor, or cephalexine
546containing further heterocyclic rings, e.g. cephalothin
Applicants
  • SRINIVAS, Jegannathan [IN]/[IN]
Inventors
  • SRINIVAS, Jegannathan
Agents
  • SURYA, Senthil
Priority Data
120/CHE/200625.01.2006IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FORMULATION COMPRISING CEFEPIME, TAZOBACTAM AND LINEZOLID
(FR) COMPOSITION À BASE DE CÉFÉPIME, DE TAZOBACTAM ET DE LINÉZOLIDE
Abstract
(EN)
The present invention is to provide a pharmaceutical composition of Cefepime and Tazobactum in fixed dose combination with Linezolid in Injectable dosage form. Tazobactum in the composition acts as Enzyme Inhibitor that enhances the antibacterial activity of Cefepime by inhibiting Betalactamases such as, Group 1 Cephalosporinases, Group 2br TEM-Betalactamases and Group 3 Metallo-Betalactamases. The active ingredients are basically Betalactam antibiotics, selected from Cefepime and combined with Tazobactum. Besides, the composition containing Cefepime and Tazobactum is combined with yet another drug, Linezolid, an Oxazolidinone, a new class of antibacterial, with exceptionally good activity against MRSA, VRSA, E.faecalis and Bacteroides. The present invention is envisaged to have a useful role in Critical conditions as an empiric therapy.
(FR)
La présente invention concerne une composition pharmaceutique de céfépime et de tazobactum associés en dose fixe à du limezolide sous forme de dose injectable. Le tazobactum de la composition agit comme un inhibiteur enzymatique qui accentue l'activité antibactérienne du céfépime en inhibant des bêtalactamases tels que les céphalosporinases, groupe 1, des TEM-bêtalactamases, groupe 2br et les métallo-bêtalactamases, groupe 3. Les principes actifs sont constitués fondamentalement par des antibiotiques bêtalactames pris dans le céfépime en association avec du tazobactum. De plus, la composition contenant du céfépime et du tazobactum est combinée à une autre médicament, le linézolide, un oxalidinone appartenant à une nouvelle classe d'antibactériens exceptionnellement efficacess contre MRSA, VRSA, E.faecalis et les bactéroïdes. La composition de la présente invention pourrait jouer un rôle utile comme thérapie empirique.
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Latest bibliographic data on file with the International Bureau