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1. (WO2007085906) FUNCTIONAL MUTANT LOXP SEQUENCES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/085906    International Application No.:    PCT/IB2006/004132
Publication Date: 02.08.2007 International Filing Date: 12.10.2006
IPC:
C12N 15/90 (2006.01), C12N 15/09 (2006.01), C12N 15/87 (2006.01)
Applicants: BC CANCER AGENCY [CA/CA]; 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3 (CA) (For All Designated States Except US).
HOLT, Robert, A. [CA/CA]; (CA) (For US Only).
MISSIRLIS, Perseus, I. [--/CA]; (CA) (For US Only)
Inventors: HOLT, Robert, A.; (CA).
MISSIRLIS, Perseus, I.; (CA)
Agent: MACEVICZ, Stephen, C.; Technology Development Office, BC Cancer Agency, 675 West 10th Avenue, British Columbia, Vancouver, British Columbia V5Z 1L3 (CA)
Priority Data:
Title (EN) FUNCTIONAL MUTANT LOXP SEQUENCES AND USES THEREOF
(FR) SÉQUENCES LOXP MUTANTES FONCTIONNELLES ET UTILISATIONS DE CELLES-CI
Abstract: front page image
(EN)Compositions comprising mutant loxP elements having a mutated spacer region In one specific embodiment, the loxP recombination elements also have one mutated inverted repeat (e.g. Iox66 right inverted repeat or Iox71 left inverted repeat) as well as a wild type inverted repeat Such elements are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different times, assembly of large polynucleotide constructs by serial site-specific recombination, and the like Pn one aspect, compositions of the invention include particular mutant spacer oligonucleotides of loxP recombination elements, the recombination elements themselves, and pairs of mutant loxP elements
(FR)L'invention concerne des procédés, des trousses et des compositions comprenant de nouveaux sites IoxP mutants. Ces sites sont particulièrement utiles dans des procédures nécessitant de muliples réactions de recombinaison spécifiques de site, y compris des délétions ou des insertions de multiples gènes ou d'autres séquences dans le même organisme, des insertions par étapes ou des délétions de gènes du même organisme à des moments différents, l'assemblage de grandes constructions polynucléotidiques par recombinaison en série spécifique de site et analogue. Dans une forme de réalisation, les compositions de l'invention comprennent des oligonucléotides mutants d'un espaceur particulier d'éléments de recombinaison d'IoxP, les éléments de recombinaison eux-mêmes et des paires de sites IoxP mutants peu ou non réactifs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)