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1. (WO2007085638) PROCESS FOR PREPARING AMINOCROTONYLAMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/085638    International Application No.:    PCT/EP2007/050752
Publication Date: 02.08.2007 International Filing Date: 25.01.2007
IPC:
C07D 293/04 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Str. 173, 55216 Ingelheim Am Rhein (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Str. 173, 55216 Ingelheim Am Rhein (DE) (DE only).
SCHROEDER, Juergen [DE/DE]; (DE) (For US Only).
DZIEWAS, Georg [DE/DE]; (DE) (For US Only).
FACHINGER, Thomas [DE/DE]; (DE) (For US Only).
JAEGER, Burkhard [DE/DE]; (DE) (For US Only).
REICHEL, Carsten [DE/DE]; (DE) (For US Only).
RENNER, Svenja [DE/DE]; (DE) (For US Only)
Inventors: SCHROEDER, Juergen; (DE).
DZIEWAS, Georg; (DE).
FACHINGER, Thomas; (DE).
JAEGER, Burkhard; (DE).
REICHEL, Carsten; (DE).
RENNER, Svenja; (DE)
Agent: HAMMANN, Heinz; Binger Str. 173, 55216 Ingelheim am Rhein (DE)
Priority Data:
06100914.8 26.01.2006 EP
Title (EN) PROCESS FOR PREPARING AMINOCROTONYLAMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES
(FR) PROCEDE DE PREPARATION DE DERIVES QUINAZOLINE A SUBSTITUTION AMINOCROTONYLAMINO
Abstract: front page image
(EN)The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have the meanings given in the claims, as well as sulphonyl derivatives of formula (XIII) and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.
(FR)La présente invention concerne un procédé amélioré de préparation de dérivés quinazoline à substitution aminocrotonylamino de formule générale (I), dans laquelle les groupes Ra, Rb, Rc et Rd sont tels que définis dans les revendications. L’invention concerne également des dérivés sulfonyle de formule (XIII) et leur utilisation en tant que composant de synthèse pour la préparation des quinazolines de formule (I). Les dérivés quinazoline de formule (I) sont des inhibiteurs de la transduction de signal médiée par les tyrosinekinases et le récepteur du facteur de croissance épidermique (EGF-R) ; elles sont donc particulièrement appropriées pour traiter les maladies tumorales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)