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Machine translation
1. (WO2007085485) LNA MODIFIED PHOSPHOROTHIOLATED OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/085485    International Application No.:    PCT/EP2007/000741
Publication Date: 02.08.2007 International Filing Date: 29.01.2007
IPC:
C07H 19/06 (2006.01), C07H 19/16 (2006.01), A61K 31/712 (2006.01), A61K 31/7125 (2006.01), A61K 31/713 (2006.01)
Applicants: SANTARIS PHARMA A/S [DK/DK]; Bøge Allé 3, DK-2970 Hørsholm (DK) (For All Designated States Except US).
ELMEN, Joacim [SE/SE]; (SE) (For US Only).
HANSEN, Henrik, Frydenlund [DK/DK]; (DK) (For US Only).
øRUM, Henrik [DK/DK]; (DK) (For US Only).
KOCH, Troels [DK/DK]; (DK) (For US Only)
Inventors: ELMEN, Joacim; (SE).
HANSEN, Henrik, Frydenlund; (DK).
øRUM, Henrik; (DK).
KOCH, Troels; (DK)
Agent: INSPICOS A/S; Bøge Allé 5, P.O. 45, DK-2970 Hørsholm (DK)
Priority Data:
60/762,920 27.01.2006 US
Title (EN) LNA MODIFIED PHOSPHOROTHIOLATED OLIGONUCLEOTIDES
(FR) OLIGONUCLÉOTIDES PHOSPHORÉS THIOLÉS MODIFIÉS PAR DES ACIDES NUCLÉIQUES VERROUILLÉS
Abstract: front page image
(EN)The current invention provides oligonucleotides which comprise a dinucleotide consisting of a 5' locked nucleic acid (LNA), a phosphorothioate intemucloside linkage bond to a 3' RNA or RNA analogue. The dinucleotide reduces the strength of hybridization of the oligonucleotide to a complementary nucleic acid target. The modification can be used to modulate hybridisation properties in both single stranded oligonucleotides and in double stranded siRNA complexes, particularly in oligonucleotides where the use of LNA results in excessively strong hybridisation properties.
(FR)La présente invention concerne des oligonucléotides comportant un dinucléotide constitué d'un acide nucléique verrouillé 5', d'une liaison internucléoside phosphoré thiolé à un analogue ARN 3' ou d'ARN. Le dinucléotide réduit la force d'hybridation de l'oligonucléotide à une cible d'acide nucléique complémentaire. La modification peut être utilisée pour moduler des propriétés d'hybridation tant dans des oligonucléotides simple brin que dans des complexes d'ARNsi double brin, notamment dans des oligonucléotides où l'utilisation d'acides nucléiques verrouillés entraîne des propriétés d'hybridation excessivement fortes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)