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1. (WO2007085067) PHARMACEUTICAL COMPOSITIONS CONTAINING DOCETAXEL AND A DEGRADATION INHIBITOR AND A PROCESS FOR OBTAINING THE SAME.
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/085067    International Application No.:    PCT/BR2006/000016
Publication Date: 02.08.2007 International Filing Date: 09.02.2006
Chapter 2 Demand Filed:    05.01.2007    
IPC:
A61K 31/337 (2006.01)
Applicants: QUIRAL QUÍMICA DO BRASIL S.A. [BR/BR]; Rua José Lourenço, 245 - Bairro São Pedro 36036-230 Juiz De Fora (BR) (For All Designated States Except US).
BIORGÂNICA LTDA. [BR/BR]; Rua José Lourenço, 245 - Bairro São Pedro, 36036-230 Juiz De Fora (BR) (For All Designated States Except US).
MACHADO, Antônio [BR/BR]; (BR) (For US Only).
MARANDUBA, Aurélio [BR/BR]; (BR) (For US Only).
GUIMARÃES, Eneida [BR/BR]; (BR) (For US Only).
MACHADO, Lívia [BR/BR]; (BR) (For US Only).
SANTIAGO JUNIOR, Marcio [BR/BR]; (BR) (For US Only).
SILVA, Maria [BR/BR]; (BR) (For US Only)
Inventors: MACHADO, Antônio; (BR).
MARANDUBA, Aurélio; (BR).
GUIMARÃES, Eneida; (BR).
MACHADO, Lívia; (BR).
SANTIAGO JUNIOR, Marcio; (BR).
SILVA, Maria; (BR)
Agent: LLC INFO CONNECTION LTDA.; Av. Dom Hélder Câmara, 5555 Sala 312 - Pilares, 20771-001 Rio De Janeiro (BR)
Priority Data:
PI 0600194-7 30.01.2006 BR
Title (EN) PHARMACEUTICAL COMPOSITIONS CONTAINING DOCETAXEL AND A DEGRADATION INHIBITOR AND A PROCESS FOR OBTAINING THE SAME.
(FR) COMPOSITIONS PHARMACEUTIQUES CONTENANT DU DOCÉTAXEL ET UN INHIBITEUR DE DÉGRADATION ET LEUR PROCÉDÉ D'OBTENTION
Abstract: front page image
(EN)Pharmaceutical compositions containing polysorbate 80, anhydrous docetaxel ( I ) or its trihydrate and an organic acid with a pKa between 2.5-4.5 employed as a degradation inhibitor. The compositions thus obtained are sterile and stable up to 30 months when stored at room temperature, corresponding to a range between 15 and 30°C, ± 1° C, and present low levels of 7-epi-docetaxel ( II ).
(FR)Compositions pharmaceutiques contenant du polysorbate 80, du docétaxel anhydre (I) ou trihydraté et un acide organique ayant un pKa dans la plage de 2,5 à 4,5, employées comme inhibiteur de dégradation. Les compositions ainsi obtenues sont stériles et stables jusqu'à 30 mois lorsqu'elles sont stockées à la température ambiante, soit une plage de 15 à 30°C, ± 1°C, et elles présentent de faibles taux de 7-épidocétaxel (II).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)