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Machine translation
1. (WO2007084875) SPIRO COMPOUNDS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/084875    International Application No.:    PCT/US2007/060537
Publication Date: 26.07.2007 International Filing Date: 14.01.2007
IPC:
A01N 43/38 (2006.01), A61K 31/40 (2006.01)
Applicants: CHEN, Guoqing, Paul [US/US]; (US)
Inventors: CHEN, Guoqing, Paul; (US)
Agent: CHEN, Paul; ADVENCHEN LABORATORIES, 9135 Reseda Blvd, Ste 238, Northridge, CA 91324 (US)
Priority Data:
60/759,601 17.01.2006 US
11/647,823 30.12.2006 US
Title (EN) SPIRO COMPOUNDS AND METHODS OF USE
(FR) COMPOSES SPIRO ET PROCEDES D’UTILISATION
Abstract: front page image
(EN)Formula (I): The present invention relates to spiro compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states such as cancers associated with protein tyrosine kinases, especially epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), to their method of use as medicaments and to their method of use in the manufacture of medicaments for use in the production of inhibition of tyrosine kinase reducing effects in warm-blooded animals such as humans.
(FR)Formule (I) : la présente invention concerne des composés spiro répondant à la formule (I), des procédés pour leur préparation, des compositions pharmaceutiques contenant ces composés en tant que principe actif, des procédés pour le traitement de pathologies telles que des cancers associés à des protéines tyrosine kinases, en particulier à un facteur de croissance épidermique (EGF) et à un facteur de croissance endothélial vasculaire (VEGF), leur procédé d’utilisation en tant que médicaments et leur procédé d’utilisation dans la fabrication de médicaments utilisés pour inhiber des effets réducteurs de la tyrosine kinase chez des animaux à sang chaud tels que des humains.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)