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Machine translation
1. (WO2007084868) TREATMENT OF DISORDERS BY ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/084868    International Application No.:    PCT/US2007/060527
Publication Date: 26.07.2007 International Filing Date: 12.01.2007
IPC:
A61K 31/415 (2006.01), A61P 9/00 (2006.01), A61P 11/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: KALYPSYS, INC. [US/US]; 10420 Wateridge Circle, San Diego, CA 92121 (US) (For All Designated States Except US).
HASSIG, Christian [US/US]; (US) (For US Only).
GAHMAN, Timothy, C. [US/US]; (US) (For US Only).
HERBERT, Mark, R. [US/US]; (US) (For US Only).
THAYER, Angelina, M. [US/US]; (US) (For US Only)
Inventors: HASSIG, Christian; (US).
GAHMAN, Timothy, C.; (US).
HERBERT, Mark, R.; (US).
THAYER, Angelina, M.; (US)
Agent: HO, Raymond; International Patent Group, Post Office Box 38129, St. Louis, MO 63138 (US)
Priority Data:
60/761,043 17.01.2006 US
Title (EN) TREATMENT OF DISORDERS BY ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE
(FR) TRAITEMENT D'UNE INFLAMMATION ET DE TROUBLES ASSOCIES PAR L'ACTIVATION DE LA REPONSE UPR (PROTEINE DEPLIEE)
Abstract: front page image
(EN)The present invention is directed to a novel method for the treatment of diseases by activating the unfolded protein response (UPR), or of inhibiting the expression of the inducible isoform of the nitric oxide synthase (iNOS) enzyme, or both. New methylpyrazole compounds which activate the UPR, downregulate iNOS, and reduce inflammatory markers are disclose herein, as are compositions comprising said compounds and their applications as pharmaceuticals for the treatment of disease.
(FR)La présente invention concerne un nouveau procédé destiné au traitement de pathologies par l'activation de la réponse UPR (protéine dépliée), ou par l'inhibition de l'expression de l'isoforme inductible d'oxyde nitrique synthétase (iNOS), ou les deux. De nouveaux composés méthylpyrazole activant la réponse UPR, diminuant le nombre d'iNOS et des marqueurs d'inflammation sont décrits dans le présent document, tout comme le sont des compositions comprenant lesdits composés et leurs applications en tant que produits pharmaceutiques destinés au traitement de pathologies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)