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1. (WO2007084730) METHOD OF IMPROVING CELL PROLIFERATION OF PANCREATIC PROGENITOR CELLS IN A PANCREATIC CELL CULTURE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/084730 International Application No.: PCT/US2007/001555
Publication Date: 26.07.2007 International Filing Date: 18.01.2007
IPC:
C12N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants: FLORIO, Monica[US/US]; US (UsOnly)
FRANCKI, Aleksandar[DE/US]; US (UsOnly)
TSANG, Wen-Ghih[US/US]; US (UsOnly)
ReNeuron, Inc.[US/US]; 2825 Santa Monica Blvd., Suite 200 Santa Monica, California 90404, US (AllExceptUS)
Inventors: FLORIO, Monica; US
FRANCKI, Aleksandar; US
TSANG, Wen-Ghih; US
Agent: WARD, Michael, R.; Morrison & Foerster, LLP 425 Market Street San Francisco, CA 94105-2402, US
Priority Data:
60/760,44520.01.2006US
Title (EN) METHOD OF IMPROVING CELL PROLIFERATION OF PANCREATIC PROGENITOR CELLS IN A PANCREATIC CELL CULTURE
(FR) PROCÉDÉ PERMETTANT D'AMÉLIORER LA PROLIFÉRATION CELLULAIRE DES CELLULES PROGÉNITRICES PANCRÉATIQUES DANS UNE CULTURE DE CELLULES PANCRÉATIQUES
Abstract:
(EN) The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.
(FR) L'invention concerne un procédé permettant d'améliorer la prolifération et la survie des cellules progénitrices pancréatiques, lequel procédé consiste à mettre les cellules en contact avec (1) un inhibiteur de caspase suffisant pour réduire l'apoptose dans les cellules endocrines pancréatiques; et avec (2) un facteur de croissance, dans une quantité suffisante pour augmenter le niveau d'Akt activé dans les cellules endocrines pancréatiques.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)