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1. (WO2007084697) PROCESS FOR PREPARING A CRYSTALLINE FORM OF TEGASEROD MALEATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/084697 International Application No.: PCT/US2007/001492
Publication Date: 26.07.2007 International Filing Date: 18.01.2007
IPC:
C07D 209/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
14
Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Applicants:
TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 Basel Street P.O. Box 3190 49131 Petah Tiqva, IL (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road P.O. Box 1090 North Wales, PA 19454-1090, US (BB)
FRENKEL, Gustavo [IL/IL]; IL (UsOnly)
INI, Santiago [IL/IL]; IL (UsOnly)
Inventors:
FRENKEL, Gustavo; IL
INI, Santiago; IL
Agent:
BRIDE, Patrick, J.; Kenyon & Kenyon LLP One Broadway New York, NY 10004-1050, US
Priority Data:
60/760,30618.01.2006US
60/872,95004.12.2006US
Title (EN) PROCESS FOR PREPARING A CRYSTALLINE FORM OF TEGASEROD MALEATE
(FR) PROCEDE DE PREPARATION D'UNE FORME CRISTALLINE DE MALEATE DE TEGASEROD
Abstract:
(EN) Provided is a process for preparing tegaserod maleate Form B comprising reacting N- amino-N'-pentylguanidine hydroiodide ('AGP-HI') and 5-Methoxy-1 H-indole-3- carbaldehyde ('MICHO') in an aqueous reaction mixture to obtain tegaserod base; extracting the tegaserod base with a water immiscible organic solvent to obtain a mixture; combining the mixture with n-propanol to obtain a slurry; and combining the slurry with maleic acid to obtain tegaserod maleate Form B.
(FR) La présente invention concerne un procédé de préparation de maléate de tégasérod.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)