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1. (WO2007084585) NON-HUMAN PRIMATE EMBRYONIC STEM AND GERM CELLS: METHODS OF USE AND METHODS OF MAKING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/084585    International Application No.:    PCT/US2007/001280
Publication Date: 26.07.2007 International Filing Date: 19.01.2007
IPC:
C07K 16/28 (2006.01), C12N 15/877 (2010.01), C12N 5/074 (2010.01), C12Q 1/02 (2006.01), C12Q 1/68 (2006.01), G01N 33/50 (2006.01), G01N 33/53 (2006.01)
Applicants: MAGEE-WOMANS HEALTH CORPORATION [US/US]; 204 Craft Avenue, Pittsburgh, Pennsylvania 15213 (US) (For All Designated States Except US).
SCHATTEN, Gerald, P. [US/US]; (US) (For US Only).
SIMERLY, Calvin [US/US]; (US) (For US Only)
Inventors: SCHATTEN, Gerald, P.; (US).
SIMERLY, Calvin; (US)
Agent: PELTO, Don; Kirkpatrick & Lockhart, Preston Gates Ellis Llp, 1735 New York Avenue, NW, Suite 500, Washington, DC 20006 (US)
Priority Data:
60/759,950 19.01.2006 US
Title (EN) NON-HUMAN PRIMATE EMBRYONIC STEM AND GERM CELLS: METHODS OF USE AND METHODS OF MAKING SAME
(FR) CELLULES SOUCHES ET GERMINALES EMBRYONNAIRES DE PRIMATES NON HUMAINS, LEURS MÉTHODES D'UTILISATION ET LEURS MÉTHODES DE FABRICATION
Abstract: front page image
(EN)The present invention provides a non-human primate (nhp) pluripotential embryonic stem (ES) cell, which can be used in several ways as described herein, including to generate chimeric primate embryos. The invention further provides methods to determine the differentiation status of an embryonic cell by comparing its transcriptional patterns with those of ES cells at particular stages of differentiation. The invention further provides a non-human primate embryonic germ (EG) cell which can also be used in several ways, including administering the differentiated EG cell line to a patient to treat a number of diseases. Also provided are methods of generating nhp ES cell + primate embryo chimeras, and methods of deriving EG cells.
(FR)L'invention concerne une cellule souche embryonnaire (ES) pluripotentielle de primate non humain (nhp), pouvant être utilisée de différentes manières, notamment pour générer des embryons de primate chimériques. L'invention concerne également des méthodes destinées à déterminer l'état de différenciation d'une cellule embryonnaire, par comparaison de ses motifs de transcription avec ceux de cellules ES à des étapes de différenciation particulières. L'invention concerne également une cellule germinale embryonnaire (EG) de primate non humain pouvant être utilisée de différentes manières, notamment pour administrer une lignée cellulaire EG différenciée à un patient, afin de traiter un certain nombre de maladies. L'invention concerne également des méthodes de génération de cellules ES nhp et de chimères d'embryons de primates, ainsi que des méthodes de dérivation de cellules EG.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)