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Machine translation
1. (WO2007084353) MYCOBACTERIAL SECA2 MUTANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/084353 International Application No.: PCT/US2007/000793
Publication Date: 26.07.2007 International Filing Date: 11.01.2007
IPC:
C12N 1/21 (2006.01) ,A61K 39/04 (2006.01)
Applicants: JACOB, William, R.[US/US]; US (UsOnly)
PORCELLI, Steven, A.[US/US]; US (UsOnly)
BRAUNSTEIN, Miriam[US/US]; US (UsOnly)
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY[US/US]; 1300 Morris Park Avenue Bronx, NY 10461, US (AllExceptUS)
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL[US/US]; Cb4105, 308 Bynum Hall Chapel Hill, NC 27599-4105, US (AllExceptUS)
Inventors: JACOB, William, R.; US
PORCELLI, Steven, A.; US
BRAUNSTEIN, Miriam; US
Agent: ARNOLD, Craig, J. ; Amster, Rothstein & Ebenstein Llp 90 Park Avenue New York, NY 10016, US
Priority Data:
60/758,94412.01.2006US
Title (EN) MYCOBACTERIAL SECA2 MUTANTS
(FR) SECA2 MUTANTS MYCOBACTERIENS
Abstract:
(EN) Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
(FR) L’invention a pour objet des mycobactéries comprenant (a) une mutation non incluse dans un gène SecA2 qui atténue la virulence de la mycobactérie chez un hôte mammifère et (b) une mutation d’un gène SecA2 qui supprime son activité. L’invention a également pour objet des mycobactéries comprenant une mutation d’un gène SecA2 qui supprime son activité, les mycobactéries n’étant ni Mycobacterium tuberculosis, ni Mycobacterium smegmatis. De plus, l’invention a pour objet des procédés d’induction d’une réponse immunitaire chez un mammifère et des procédés d’induction d’une réponse immunitaire à une mycobactérie pathogène chez un humain à l’aide des mutants mycobactériens décrits plus haut.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)