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Pub. No.:    WO/2007/084162    International Application No.:    PCT/US2006/012795
Publication Date: 26.07.2007 International Filing Date: 06.04.2006
C07C 251/24 (2006.01), C07C 255/61 (2006.01), A61K 31/166 (2006.01), A61K 31/277 (2006.01), A61P 35/04 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street, Cambridge, MA 02138 (US) (For All Designated States Except US).
SINCLAIR, David, A. [AU/US]; (US) (For US Only).
MAI, Antonello [IT/IT]; (IT) (For US Only)
Inventors: SINCLAIR, David, A.; (US).
MAI, Antonello; (IT)
Agent: CLAUSS, Isabelle, M.; Patent Group, Foley Hoag LLP, 155 Seaport Boulevard, Boston, MA 02210 (US)
Priority Data:
60/669,484 08.04.2005 US
60/700,869 20.07.2005 US
Abstract: front page image
(EN)Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell or a molecule with a sirtuin inhibitory compound that decreases the activity of a sirtuin and thereby reduces the life span of a cell, kills the cell or renders it suspectible to certain cell stresses including radiation and chemotherapy. Other methods include treating pathogens expressing a sirtuin.
(FR)La présente invention concerne des compositions et des procédés de traitement et de prévention du cancer et de maladies autoimmunes. Ces compositions comprennent un composé inhibiteur de sirtuine qui diminue l'activité d'une sirtuine, telle que SIRTI ou Dir2. Des procédés de l'invention consistent à mettre en contact une cellule ou une molécule avec un composé inhibiteur de sirtuine qui diminue l'activité d'une sirtuine, réduisant ainsi la durée de vie d'une cellule, tuant la cellule ou la rendant sensible à certains stress cellulaires, notamment au rayons et à la chimiothérapie. D'autres procédés consistent à traiter des pathogènes exprimant une sirtuine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)