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1. (WO2007083904) C-KIT ACTIVATION INHIBITOR, SKIN WHITENING COMPOUND AND COMPOSITION FOR SKIN WHITENING CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/083904 International Application No.: PCT/KR2007/000227
Publication Date: 26.07.2007 International Filing Date: 12.01.2007
IPC:
A61K 8/49 (2006.01) ,A61Q 19/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
49
containing heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
02
for chemically bleaching or whitening the skin
Applicants:
LG HOUSEHOLD & HEALTH CARE LTD. [KR/KR]; 20 Yoido-dong, Youngdungpo-gu Seoul, 150-721, KR (AllExceptUS)
KIM, Ho-Jeoung [KR/KR]; KR (UsOnly)
JIN, Mu-Hyun [KR/KR]; KR (UsOnly)
KIM, Byong-Jun [KR/KR]; KR (UsOnly)
KANG, Sang-Jin [KR/KR]; KR (UsOnly)
Inventors:
KIM, Ho-Jeoung; KR
JIN, Mu-Hyun; KR
KIM, Byong-Jun; KR
KANG, Sang-Jin; KR
Agent:
PHIL & ONZI Int'l Patent & Law Firm; 4f., Byukcheon Bldg., 1597-5 Seocho-dong, Seocho-gu Seoul 137-876, KR
Priority Data:
10-2006-000536918.01.2006KR
10-2006-002668323.03.2006KR
Title (EN) C-KIT ACTIVATION INHIBITOR, SKIN WHITENING COMPOUND AND COMPOSITION FOR SKIN WHITENING CONTAINING THE SAME
(FR) INHIBITEUR DE L'ACTIVATION DE C-KIT, COMPOSÉ DE BLANCHIMENT DE LA PEAU, ET COMPOSITION DE BLANCHIMENT DE LA PEAU CONTENANT CEUX-CI
Abstract:
(EN) Disclosed are a c-Kit activation inhibitor, a skin whitening compound and a composition for skin whitening comprising the skin whitening compound as an active ingredient. The c-Kit activation inhibitor of the present invention is a flavone derivative selected from the group consisting of the compounds represented by Formulas 1 to 10. The flavone derivative inhibits activity of the c-Kit associated with melanin synthesis, melanocyte differentiation and maturity, etc. Accordingly, the above-mentioned flavone derivatives are useful as skin whitening compound, and the cosmetic compositions comprising the flavone derivatives as an active ingredient can be highly effectively used for skin whitening, for example treating melasma, freckles, etc.
(FR) L'invention concerne un inhibiteur de l'activation de c-Kit, un composé de blanchiment de la peau, et une composition de blanchiment de la peau comprenant ledit composé de blanchiment de la peau comme principe actif. L'inhibiteur d'activation de c-Kit de l'invention est un dérivé de flavone sélectionné dans le groupe comprenant des composés de formule 1 à 10. Le dérivé de flavone inhibe l'activité de c-Kit qui est associée à une synthèse de mélanine, à la différenciation et à la maturité des mélanocytes, etc. Par conséquent, les dérivés flavone susmentionnés sont utiles en tant que composés de blanchiment de la peau, et les compositions cosmétiques comprenant les dérivés de flavone de l'invention en tant que principe actif, peuvent être utilisées pour blanchir la peau de manière efficace, par exemple pour traiter un mélasme, des taches de rousseur etc.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Korean (KO)
Also published as:
VN18241JP2009523786CN101370470