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1. (WO2007083858) COMPOSITION COMPRISING THE EXTRACT OF SIEGESBECKIAE HERBA FOR PREVENTING AND TREATING ARTHRITIS AND THE USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/083858 International Application No.: PCT/KR2006/000647
Publication Date: 26.07.2007 International Filing Date: 24.02.2006
IPC:
A61K 36/28 (2006.01) ,A23L 1/29 (2006.01) ,A61P 19/02 (2006.01)
Applicants: PARK, Dong-Suk[KR/KR]; KR (UsOnly)
YOO, Myung Chul[KR/KR]; KR (UsOnly)
CHOI, Do-Young[KR/KR]; KR (UsOnly)
LEE, Jae-Dong[KR/KR]; KR (UsOnly)
CHO, Yong-Baik[KR/KR]; KR (UsOnly)
KIM, Nam-Jae[KR/KR]; KR (UsOnly)
CHO, Eun-Mi[KR/KR]; KR (UsOnly)
HUH, Jeong-Eun[KR/KR]; KR (UsOnly)
BAEK, Yong-Hyeon[KR/KR]; KR (UsOnly)
HONG, Seung Jae[KR/KR]; KR (UsOnly)
INDUSTRY ACADEMIC COOPERATION FOUNDATION OF KYUNGHEE UNIVERSITY[KR/KR]; Seocheon 1-ri, Giheung-eup Yongin-si, Gyeonggi-do 449-906, KR (AllExceptUS)
Inventors: PARK, Dong-Suk; KR
YOO, Myung Chul; KR
CHOI, Do-Young; KR
LEE, Jae-Dong; KR
CHO, Yong-Baik; KR
KIM, Nam-Jae; KR
CHO, Eun-Mi; KR
HUH, Jeong-Eun; KR
BAEK, Yong-Hyeon; KR
HONG, Seung Jae; KR
Agent: SHIN, Dong In; D.I. International Patent Office 501, Dong Seo Bldg., #1451-30 Seocho-dong, Seocho-gu Seoul 137-070, KR
Priority Data:
10-2006-000568419.01.2006KR
Title (EN) COMPOSITION COMPRISING THE EXTRACT OF SIEGESBECKIAE HERBA FOR PREVENTING AND TREATING ARTHRITIS AND THE USE THEREOF
(FR) COMPOSITION COMPORTANT L'EXTRAIT DE SIEGESBECKIAE HERBA POUR LA PRÉVENTION ET LE TRAITEMENT DE L'ARTHRITE ET SON UTILISATION
Abstract: front page image
(EN) The extract of Siegesbeckiae herba of the present invention showed potent inhibitory effect on the dissociation of proteoglycan and type II collagen in chondrocyte and cartilage tissue and protecting effect on cartilage due to the inhibition of MMP-I, MMP- 3 and MMP- 13 activity and the restoring effect on cartilage tissue, the anti-inflammatory and antiphlogistic effect in edema animal model, anti-inflammatory effect confirmed by the inhibition test on PGE2 activity through COX-2 inhibition and the inhibition test of the reproduction of TNF-α and NO, it can be used as the therapeutics or health food for treating and preventing arthritic disease.
(FR) La présente invention concerne un extrait de Siegesbeckiae herba présentant un effet inhibiteur sur la dissociation de protéoglycanne et de collagène de type II dans les chondrocytes et le tissu cartilagineux et un effet de protection sur le cartilage grâce à l'inhibition de l'activité de MMP-1, MMP- 3 et MMP- 13 et un effet de restauration sur le tissu cartilagineux, un effet anti-inflammatoire et anti-phlogistique dans un modèle animal d'oedème, un effet anti-inflammatoire confirmé par le test d'inhibition de l'activité PGE2 par l'inhibition de COX-2 et le test d'inhibition de la reproduction de TNF-α et NO. Il peut être utilisé comme agents thérapeutiques ou alimentation de santé pour le traitement et la prévention de maladie arthritique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Korean (KO)