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1. (WO2007083243) AN IMPROVED PROCESS FOR THE PREPARATION OF RISEDRONATE SODIUM HEMI-PENTAHYDRATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/083243    International Application No.:    PCT/IB2007/000216
Publication Date: 26.07.2007 International Filing Date: 15.01.2007
IPC:
C07F 9/58 (2006.01)
Applicants: AUROBINDO PHARMA LIMITED [IN/IN]; Aurobindo Pharma Limited, Plot No 2, Maitrivihar, Ameerpet, Hyderabad 500038 (IN) (For All Designated States Except US).
DIVVELA, Venkata, Naga, Srinivasa, Rao [IN/IN]; (IN) (For US Only).
RACHA, Lenin [IN/IN]; (IN) (For US Only).
DANDALA, Ramesh [IN/IN]; (IN) (For US Only).
MEENAKSHISUNDERAM, Sivakumaran [IN/IN]; (IN) (For US Only)
Inventors: DIVVELA, Venkata, Naga, Srinivasa, Rao; (IN).
RACHA, Lenin; (IN).
DANDALA, Ramesh; (IN).
MEENAKSHISUNDERAM, Sivakumaran; (IN)
Priority Data:
94/CHE/2006 20.01.2006 IN
Title (EN) AN IMPROVED PROCESS FOR THE PREPARATION OF RISEDRONATE SODIUM HEMI-PENTAHYDRATE
(FR) PROCEDE AMELIORE DE PREPARATION D’HEMIPENTAHYDRATE DE RISEDRONATE DE SODIUM
Abstract: front page image
(EN)The present invention relates to an improved process for the selective crystallization of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium in pure hemi-pentahydrate form of Formula (I), by converting 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid into organic amine salt followed by replacing it with sodium salt.
(FR)La présente invention concerne un procédé amélioré de cristallisation sélective du sel de sodium de l’acide 3-pyridyl-1-hydroxyéthylidène-1,1-bisphosphonique sous la forme hémipentahydrate pure répondant à la formule (I), par la conversion de l'acide 3-pyridyl-1-hydroxyéthylidène-1,1-bisphosphonique en sel d'amine organique suivie de son remplacement par un sel de sodium.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)