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1. (WO2007083175) ANTIVIRAL BIFUNCTIONAL MOLECULES, METHODS OF CONSTRUCTION AND METHODS OF TREATING VIRUS-INDUCED CANCER THEREWITH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/083175    International Application No.:    PCT/IB2006/001431
Publication Date: 26.07.2007 International Filing Date: 17.01.2006
IPC:
C12N 15/12 (2006.01), C12N 15/63 (2006.01), C07K 14/435 (2006.01), A61P 35/00 (2006.01), C12P 21/02 (2006.01)
Applicants: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY [CN/CN]; No. 37 GuoXueXing, Chengdu, 610041 Sichuan (CN) (For All Designated States Except US).
QIU, Xiao-Qing [CN/CN]; (CN) (For US Only)
Inventors: QIU, Xiao-Qing; (CN)
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8/F, Vantone New World Plaza, 2 Fuchengmenwai Street, Beijing 100037 (CN)
Priority Data:
Title (EN) ANTIVIRAL BIFUNCTIONAL MOLECULES, METHODS OF CONSTRUCTION AND METHODS OF TREATING VIRUS-INDUCED CANCER THEREWITH
(FR) MOLÉCULES ANTIVIRALES BIFONCTIONNELLES, PROCÉDÉS POUR LES PRODUIRE ET PROCÉDÉS POUR TRAITER UN CANCER INDUIT PAR VIRUS AU MOYEN DE CELLES-CI
Abstract: front page image
(EN)The present invention relates to molecules that are capable of killing cells. The molecules comprise a targeting agent and a channel-forming moiety. The molecules may be polypeptides. The present invention also relates to polynucleotide sequences encoding the polypeptides of the invention. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is an antibody. Methods of treatment by administering the molecules of the present invention are also provided.
(FR)La présente invention concerne des molécules capables de tuer des cellules. Ces molécules comprennent un agent de ciblage et une partie de formation de canal. Les molécules peuvent être des polypeptides. Cette invention concerne également des séquences polynucléotidiques codant lesdits polypeptides. Dans un mode de réalisation préféré, la partie de formation de canal comprend une colicine et l'agent de ciblage est un anticorps. En outre, cette invention concerne des procédés de traitement qui consistent à administrer lesdites molécules.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)