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1. (WO2007082946) SOLID FORMS OF A PYRROLOPYRIMIDINE DERIVATIVE AND THEIR USE AS ANTI-TUMOR AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/082946 International Application No.: PCT/EP2007/050567
Publication Date: 26.07.2007 International Filing Date: 19.01.2007
Chapter 2 Demand Filed: 23.05.2007
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 35/00 (2006.01)
Applicants: MUTZ, Michael[DE/DE]; DE (UsOnly)
FISCHER, Reto[CH/CH]; CH (UsOnly)
NOVARTIS AG[CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
Inventors: MUTZ, Michael; DE
FISCHER, Reto; CH
Agent: GRAFF, Alan; Novartis AG Corporate Intellectual Property Lichstrasse 35 CH-4056 Basel, CH
Priority Data:
60/761,22423.01.2006US
Title (EN) SOLID FORMS OF A PYRROLOPYRIMIDINE DERIVATIVE AND THEIR USE AS ANTI-TUMOR AGENTS
(FR) FORMES SOLIDES D’UN DERIVE PYRROLOPYRIMIDINE ET LEUR UTILISATION ANTITUMORALE
Abstract:
(EN) The invention relates to new crystalline forms of {6-[4-{4-ethyl-piperazin-1 -ylmethyl)- phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-((R)-1-phenyl-ethyl)-amine, the process for the preparation of these crystalline forms of {6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl}-((R)-1 -phenyl-ethyl)-amine, compositions containing these crystalline forms of {6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d ]pyrimidin-4-yl}-((R)-1-phenyl-ethyl)-amine, and the use of these crystalline forms of {6-[4-(4-ethyl- piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-{(R)-1-phenyl-ethyl)-amine in diagnostic methods or therapeutic treatment of warm-blooded animals, especially humans.
(FR) La présente invention concerne de nouvelles formes cristallines de la {6-[4-{4-éthyl-pipérazin-1-ylméthyl)phényl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-((R)-1-phényléthyl)amine. L’invention concerne également un procédé de préparation desdites formes cristallines et des compositions les contenant, ainsi que l’utilisation desdites formes cristallines dans la cadre de méthodes diagnostiques ou du traitement thérapeutique d’animaux à sang chaud, en particulier des êtres humains.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)