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1. (WO2007082533) ISOMERISATION OF PHARMACEUTICAL INTERMEDIATES

Pub. No.:    WO/2007/082533    International Application No.:    PCT/DK2006/000244
Publication Date: Fri Jul 27 01:59:59 CEST 2007 International Filing Date: Tue May 09 01:59:59 CEST 2006
IPC: C07C 401/00
C07B 37/08
Applicants: LEO PHARMA A/S
FOLKMANN, Michael, Peter
HANSEN, Erik, Tomgaard
Inventors: FOLKMANN, Michael, Peter
HANSEN, Erik, Tomgaard
Title: ISOMERISATION OF PHARMACEUTICAL INTERMEDIATES
Abstract:
The present invention relates to an isomerisation method of vitamin D analogues, such as compounds useful for the synthesis of calcipotriol, and to and to the use of a flow- through photoreactor or continuous flow photoreactor reactor for making said vitamin D analogues. The present invention relates further to the use of intermediates produced with said method for making calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof.