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Pub. No.:    WO/2007/082533    International Application No.:    PCT/DK2006/000244
Publication Date: 26.07.2007 International Filing Date: 08.05.2006
C07C 401/00 (2006.01), C07B 37/08 (2006.01)
Applicants: LEO PHARMA A/S [DK/DK]; Industriparken 55, DK-2750 Ballerup (DK) (For All Designated States Except US).
FOLKMANN, Michael, Peter [DK/DK]; (DK) (For US Only).
HANSEN, Erik, Tomgaard [DK/DK]; (DK) (For US Only)
Inventors: FOLKMANN, Michael, Peter; (DK).
HANSEN, Erik, Tomgaard; (DK)
Agent: DEUSSEN, Heinz-Josef; Principal Patent Counsel, Leo Pharma A/S, Industriparken 55, DK-2750 Ballerup (DK)
Priority Data:
60/783,076 17.03.2006 US
Abstract: front page image
(EN)The present invention relates to an isomerisation method of vitamin D analogues, such as compounds useful for the synthesis of calcipotriol, and to and to the use of a flow- through photoreactor or continuous flow photoreactor reactor for making said vitamin D analogues. The present invention relates further to the use of intermediates produced with said method for making calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof.
(FR)La présente invention concerne une méthode d'isomérisation d'analogues de la vitamine D, tels que des composés pouvant être employés dans la synthèse du calcipotriol, ainsi que l'emploi d'un réacteur de type photoréacteur à écoulement ou photoréacteur à flux continu pour la fabrication desdits analogues de vitamine D. La présente invention concerne en outre l'emploi des intermédiaires produits par le biais de ladite méthode pour la fabrication du calcipotriol ou du calcipotriol monohydrate, ou des formules pharmaceutiques les incluant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)