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1. (WO2007081571) CETP INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/081571    International Application No.:    PCT/US2006/049505
Publication Date: 19.07.2007 International Filing Date: 29.12.2006
C07D 263/16 (2006.01), A61K 31/421 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
ALI, Amjad [GB/US]; (US) (For US Only).
LU, Zhijian [US/US]; (US) (For US Only).
SINCLAIR, Peter, J. [US/US]; (US) (For US Only).
TAYLOR, Gayle, E. [US/US]; (US) (For US Only).
THOMPSON, Christopher, F. [US/US]; (US) (For US Only).
SMITH, Cameron, J. [AU/US]; (US) (For US Only).
DOWST, Adrian, A. [US/US]; (US) (For US Only).
CHEN, Yi-heng [--/US]; (US) (For US Only)
Inventors: ALI, Amjad; (US).
LU, Zhijian; (US).
SINCLAIR, Peter, J.; (US).
TAYLOR, Gayle, E.; (US).
THOMPSON, Christopher, F.; (US).
SMITH, Cameron, J.; (US).
DOWST, Adrian, A.; (US).
CHEN, Yi-heng; (US)
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/755,251 30.12.2005 US
Abstract: front page image
(EN)Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B or R2 is a phenyl group which has an ortho amine or aminomethyl substituent which is further substituted, and the other of B or R2 is also a cyclic group.
(FR)Des composés à structure de formule (I), y compris des sels pharmaceutiquement acceptables de ces composés, sont des inhibiteurs de CETP qui s'avèrent utiles pour augmenter le cholestérol HDL, réduire le cholestérol LDL, traiter ou prévenir l'athérosclérose. Dans les composés de formule (I), l'un des éléments B ou R2 est un groupe phényle doté d'un substituant ortho-amine ou aminométhyle lui-même substitué, l'autre élément B ou R2 étant aussi un groupe cyclique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)