WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |

Search International and National Patent Collections
World Intellectual Property Organization
Machine translation
1. (WO2007081569) CETP INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/081569    International Application No.:    PCT/US2006/049503
Publication Date: 19.07.2007 International Filing Date: 29.12.2006
C07D 403/02 (2006.01), C07D 263/16 (2006.01), A61K 31/4439 (2006.01), A61K 31/421 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
ALI, Amjad [GB/US]; (US) (For US Only).
LU, Zhijian [US/US]; (US) (For US Only).
SINCLAIR, Peter, J. [US/US]; (US) (For US Only).
CHEN, Yi-Heng [--/US]; (US) (For US Only).
SMITH, Cameron, J. [AU/US]; (US) (For US Only).
LI, Hong [CN/US]; (US) (For US Only).
THOMPSON, Christopher, F. [US/US]; (US) (For US Only)
Inventors: ALI, Amjad; (US).
LU, Zhijian; (US).
SINCLAIR, Peter, J.; (US).
CHEN, Yi-Heng; (US).
SMITH, Cameron, J.; (US).
LI, Hong; (US).
THOMPSON, Christopher, F.; (US)
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/755,541 30.12.2005 US
Abstract: front page image
(EN)Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B.
(FR)Des composés à structure de formule (I), y compris des sels pharmaceutiquement acceptables de ces composés, sont des inhibiteurs de CETP qui s'avèrent utiles pour augmenter le cholestérol HDL, réduire le cholestérol LDL, traiter ou prévenir l'athérosclérose. Dans les composés de formule (I), B est un groupe cyclique autre que phényle et B a un substituant cyclique en position ortho relativement à la position où B est lié au résidu de la structure de formule (I). Le noyau à 5 membres de formule (I) a un deuxième substituant cyclique en plus de B.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)